Premature infants are born with developing lungs burdened by surfactant deficiency and a
dearth of antioxidant defense systems. Survival rate of such infants has significantly …

Sphingolipids comprise a class of bioactive lipids that are involved in a variety of
pathophysiologic processes, including cell death and survival. Ceramide and sphingosine-1 …

Following the discovery of ceramide as the central signaling and metabolic relay among
sphingolipids, studies of its involvement in lung health and pathophysiology have …

The aim of this study was to characterise lung function and bronchoalveolar lavage
sphingolipid profile in newborn mice during hyperoxia exposure and recovery in room air …

Abstract Background Sphingosine-1-Phosphate (S1P) is a bioactive lipid and an
intracellular as well as an extracellular signaling molecule. S1P ligand specifically binds to …

Sphingolipids are a diverse class of signaling molecules implicated in many important
aspects of cellular biology, including growth, differentiation, apoptosis, and autophagy …

Sphingolipids form a broad class of lipids with diverse functions ranging from membrane
constituents to intracellular second messengers and extracellular mediators. They can be …

Chronic obstructive pulmonary disease (COPD) includes a spectrum of conditions that have
in common varying degrees of airflow obstruction, such as chronic bronchitis and …

A better understanding of the pathogenesis of distinct chronic obstructive pulmonary disease
(COPD) phenotypes will improve diagnostic and therapeutic options for this common …

Sphingolipid bioactivities in the respiratory airways and the roles of the proteins that handle
them have been extensively investigated. Gas or inhaled particles or microorganisms come …