Animal studies have suggested an altered response to opiate agonists and antagonists as
well as an altered pain threshold in diabetic animals. In the studies reported herein, a 50 g …

The effect exerted by different hyperglycemic states on the pain threshold and on the
analgesic potential of morphine was studied in male Sabra rats with the hot plate device …

Abnormal sensations and pain are features of approximately 10% of all cases of diabetic
neuropathy and can cause marked diminution in the quality of life for these patients. The …

Painful neuropathy is common in human diabetes. In rats, experimental diabetes results in
altered pain sensitivity. We examined the effect of chronic insulin treatment on diabetes …

Diabetes mellitus is one of the most rapidly growing health concerns in the developed world
due to the persistence of type 1 (insulin-deficient) diabetes and the dramatic increase in type …

Pain threshold was assessed via tail flick latency in streptozotocin diabetic rats following a 1-
month period of either good or poor diabetic control. Additionally, tail flick latencies were …

Hyperactivity of nociceptive C-fibers has been recently described in diabetic BB/Wistar rats.
This study assesses the association of hyperalgesia, using an analgesy-meter, with elevated …

Neuropathic pain is a common phenomenon resulting from injury to the central or peripheral
nervous system. The means by which diabetes results in nerve injury is unclear but the effect …

The streptozocin-induced diabetic rat has been put forward as a model of chronic pain with
signs of hyperalgesia and allodynia that may reflect signs observed in diabetic humans. The …

Insulin-dependent diabetes mellitus (IDDM) is associated with several complications,
including painful diabetic neuropathy. Both animal and human investigations suggest an …