[HTML][HTML] Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects

KM Yap, M Sekar, YS Wu, SH Gan, NNIM Rani… - Saudi Journal of …, 2021 - Elsevier
Breast cancer (BC) has high incidence and mortality rates, making it a major global health
issue. BC treatment has been challenging due to the presence of drug resistance and the …

Molecular mechanisms of action of hesperidin in cancer: Recent trends and advancements

V Aggarwal, HS Tuli, F Thakral… - Experimental …, 2020 - journals.sagepub.com
Hesperidin belongs to flavanones class of flavonoids and is known to possess broad-
spectrum applicability to prevent dreadful diseases such as cardiovascular disease …

The role of hesperidin in cell signal transduction pathway for the prevention or treatment of cancer

A Ahmadi, A Shadboorestan, SF Nabavi… - Current medicinal …, 2015 - ingentaconnect.com
During past two decades, plant-derived bioactive compounds have been reported as novel
therapeutic agents for prevention and/or mitigation of different human diseases such as …

A mechanistic review of the anticancer potential of hesperidin, a natural flavonoid from citrus fruits

P Pandey, F Khan - Nutrition Research, 2021 - Elsevier
Hesperidin, a phytoactive compound, is an abundant and economical dietary bioflavonoid
possessing numerous biological and medicinal benefits. Several studies have strongly …

Hesperidin, a bioflavonoid in cancer therapy: a review for a mechanism of action through the modulation of cell signaling pathways

AH Rahmani, AY Babiker, S Anwar - Molecules, 2023 - mdpi.com
Cancer represents one of the most frequent causes of death in the world. The current
therapeutic options, including radiation therapy and chemotherapy, have various adverse …

Hesperidin: A promising anticancer agent from nature

KP Devi, T Rajavel, SF Nabavi, WN Setzer… - Industrial crops and …, 2015 - Elsevier
Cancer is major health problem in the worldwide which refers to a group of diseases caused
by abnormal cell growth with invasive potentials. There are different environmental and …

Anti-proliferative, apoptotic and signal transduction effects of hesperidin in non-small cell lung cancer cells

Z Birsu Cincin, M Unlu, B Kiran, E Sinem Bireller… - Cellular Oncology, 2015 - Springer
Purpose Hesperidin, a glycoside flavonoid, is thought to act as an anti-cancer agent, since it
has been found to exhibit both pro-apoptotic and anti-proliferative effects in several cancer …

Chemotherapeutic potential of hesperetin for cancer treatment, with mechanistic insights: A comprehensive review

M Sohel, H Sultana, T Sultana, M Al Amin, S Aktar… - Heliyon, 2022 - cell.com
Background Cancer has become a significant concern in the medical sector with increasing
disease complexity. Although some available conventional treatments are still a blessing for …

Hesperidin suppressed proliferations of both Human breast cancer and androgen‐dependent prostate cancer cells

CJ Lee, L Wilson, MA Jordan, V Nguyen… - Phytotherapy …, 2010 - Wiley Online Library
Hesperidin, a flavonoid derived from citrus fruits, has been reported to show various
biological effects including anticancer activity. This study investigated whether hesperidin …

Therapeutic potential of hesperidin and its aglycone hesperetin: Cell cycle regulation and apoptosis induction in cancer models

JMPF de Oliveira, C Santos, E Fernandes - Phytomedicine, 2020 - Elsevier
Background The ability of cancer cells to divide without restriction and to escape
programmed cell death is a feature of the proliferative state. Citrus flavanones are flavonoids …