[HTML][HTML] Pathway analysis of seven common diseases assessed by genome-wide association
A Torkamani, EJ Topol, NJ Schork - Genomics, 2008 - Elsevier
Recent genome-wide association studies (GWAS) have identified DNA sequence variations
that exhibit unequivocal statistical associations with many common chronic diseases …
that exhibit unequivocal statistical associations with many common chronic diseases …
GRASP: analysis of genotype–phenotype results from 1390 genome-wide association studies and corresponding open access database
R Leslie, CJ O'Donnell, AD Johnson - Bioinformatics, 2014 - academic.oup.com
We created a deeply extracted and annotated database of genome-wide association studies
(GWAS) results. GRASP v1. 0 contains> 6.2 million SNP-phenotype association from among …
(GWAS) results. GRASP v1. 0 contains> 6.2 million SNP-phenotype association from among …
[PDF][PDF] A short history of the genome-wide association study: where we were and where we are going
S Ikegawa - Genomics & informatics, 2012 - synapse.koreamed.org
Recent rapid advances in genetic research are ushering us into the genome sequence era,
where an individual's genome information is utilized for clinical practice. The most …
where an individual's genome information is utilized for clinical practice. The most …
Genome-wide association studies: potential next steps on a genetic journey
MI McCarthy, JN Hirschhorn - Human molecular genetics, 2008 - academic.oup.com
Genome-wide association studies have successfully identified numerous loci at which
common variants influence disease risk or quantitative traits. Despite these successes, the …
common variants influence disease risk or quantitative traits. Despite these successes, the …
Rare variants create synthetic genome-wide associations
Genome-wide association studies (GWAS) have now identified at least 2,000 common
variants that appear associated with common diseases or related traits (http://www. genome …
variants that appear associated with common diseases or related traits (http://www. genome …
Strategies for fine-mapping complex traits
SL Spain, JC Barrett - Human molecular genetics, 2015 - academic.oup.com
Genome-wide association studies (GWAS) have identified thousands of robust and
replicable genetic associations for complex disease. However, the identification of the …
replicable genetic associations for complex disease. However, the identification of the …
Phenotype–Genotype Integrator (PheGenI): synthesizing genome-wide association study (GWAS) data with existing genomic resources
EM Ramos, D Hoffman, HA Junkins, D Maglott… - European Journal of …, 2014 - nature.com
Rapidly accumulating data from genome-wide association studies (GWASs) and other large-
scale studies are most useful when synthesized with existing databases. To address this …
scale studies are most useful when synthesized with existing databases. To address this …
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
The overwhelming majority of participants in current genetic studies are of European
ancestry. To elucidate disease biology in the East Asian population, we conducted a …
ancestry. To elucidate disease biology in the East Asian population, we conducted a …
Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases
Genome-wide association studies (GWAS) have led to a rapid increase in available data on
common genetic variants and phenotypes and numerous discoveries of new loci associated …
common genetic variants and phenotypes and numerous discoveries of new loci associated …
Replicability and prediction: lessons and challenges from GWAS
Since the publication of the Wellcome Trust Case Control Consortium (WTCCC) landmark
study a decade ago, genome-wide association studies (GWAS) have led to the discovery of …
study a decade ago, genome-wide association studies (GWAS) have led to the discovery of …