Muscular dystrophy: Experimental animal models and therapeutic approaches

G Gaina - Experimental and Therapeutic Medicine, 2021 - spandidos-publications.com
The muscular dystrophies are a heterogeneous group of genetically inherited diseases
characterized by muscle weakness and progressive wasting, which can cause premature …

[引用][C] Factors affecting phenotypic expression of dystrophy in skeletal muscles of the dystrophic mouse (dy/dy)

E Jaros, D Johnstone - … into the origin and treatment of …, 1984 - Excerpta Medica Amsterdam

The pathogenesis and therapy of muscular dystrophies

S Guiraud, A Aartsma-Rus, NM Vieira… - Annual review of …, 2015 - annualreviews.org
Current molecular genomic approaches to human genetic disorders have led to an
explosion in the identification of the genes and their encoded proteins responsible for these …

Genetic treatments in muscular dystrophies

F Muntoni, D Wells - Current opinion in neurology, 2007 - journals.lww.com
These studies should provide proof of principle of these experimental approaches in
humans. It is likely that further refinement will be required before extending their use to the …

Distinct genetic regions modify specific muscle groups in muscular dystrophy

KA Swaggart, A Heydemann… - Physiological …, 2011 - journals.physiology.org
Phenotypic expression in the muscular dystrophies is variable, even with the identical
mutation, providing strong evidence that genetic modifiers influence outcome. To identify …

PCR analysis of muscular dystrophy in mdx mice

JS Chamberlain, SF Phelps, GA Cox… - Molecular and cell …, 1993 - Springer
Animal models for human genetic diseases provide a biological system in which many of the
basic features of a disease can be studied and in which approaches for therapeutic …

Muscular dystrophies

I Nishino, E Ozawa - Current opinion in neurology, 2002 - journals.lww.com
Several possible mechanisms causing muscular dystrophy were discussed. Defects in
extracellular molecules have more significant effects resulting mainly in congenital muscular …

[引用][C] Hereditary mouse muscular dystrophy with particular emphasis on patho-genesis and attempts at therapy.

WT West, H Meier, WG Hoag - 1966 - cabidigitallibrary.org
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Muscular dystrophies: genes to pathogenesis

I Dalkilic, LM Kunkel - Current opinion in genetics & development, 2003 - Elsevier
Muscular dystrophies are a genetically heterogeneous group of degenerative muscle
disorders. Nearly 30 genes are known to give rise to various forms of muscular dystrophy …

Research in muscular dystrophy

JN Walton - nature, 1970 - nature.com
Research in Muscular Dystrophy Page 1 © 1970 Nature Publishing Group NATURE VOL.
228 OCTOBER 31 1970 417 Research in Muscular Dystrophy by JN WALTON Department …