Many studies have correlated reductions in gap junctional intercellular communication (a)
with altered cellular growth, tumor promotion, and neoplastic transformation. To test directly …

Antisense gene constructs have been very useful in the functional analysis of genes and
their products. In this report we used a connexin 43 (Cx43) antisense gene construct to study …

The loss of homeostasis which characterizes tumor growth is probably the result of a
deregulated intercellular communication capacity of the cancer cells. The deregulation of …

In this study, we investigated whether the tumor promoters, 12-O-tetradecanoylphorbol-13-
acetate (TPA), phenobarbital (PB), and 1, 1-bis (p-chlorophenyl)-2, 2, 2-trichloroethane …

Gap junctional intercellular communication (GJIC) maintains normal growth and
differentiation of cells in a tissue. The intercellular molecules traversing gap junctions are …

To study the biochemical basis of gap‐junctional intercellular communication (GJIC) and its
role in tumorigenesis, a mammalian cell expression vector carrying both a rat connexin 43 …

Gap junctions are cellular structures which permit direct exchanges of small molecules from
cytoplasm to cytoplasm in most of the cells of metazoan organisms. For four decades, it has …

Gap junctions comprised of connexin proteins are involved in direct intercellular
communication and the regulation of cell behaviour and homeostasis. Reduced connexin …

A HeLa cell line, obtained from the ATCC, was cloned and found to exhibit a spectrum of in
vitro and in vivo growth characteristics as well as variable expression of endogenous …

Gap-junctional intercellular communication is thought to be essential for maintaining cellular
homeostasis and growth control. Its perturbation entails toxicological implications and it has …