Sickle cell disease is enormously variable in its expression and outcome. In addition to this
intrinsic variability are the problems of symptomatic selection biasing observations towards …

Background: Sickle cell disease causes significant morbidity and mortality and affects the
economic and healthcare status of many countries. Yet historically, the disease has not had …

Serves as a guide for the health care worker involved in the management of patients with
sickle cell disease. Represents a collective summary of experiences with therapeutic …

Sickle cell disease results in significant morbidity and mortality for those affected with this
disease. Despite the fact that every case of sickle cell disease results from the same genetic …

The familial pattern of recurring pain and early death seen so often among those affected by
sickle cell disease has been long recognized within African cultures, though its first clear …

In the United States, sickle cell disease affects approximately 1 in 350 African-American
newborn infants each year, and approximately 72,000 individuals total. Sickle cell disease is …

The ever-increasing body of information regarding the molecular pathogenesis of sickle cell
disease has raised expectations that a specific and effective therapy could be devised to …

Over the past few decades, the life expectancy of patients with sickle cell disease has
improved. This has been because of better supportive care and greater awareness of the …

Although sickle cell disease has been known for years and many of its manifestations have
been recognized, the “natural history” or clinical course of the disease from early childhood …

Treatment advances over the past 25 years have significantly decreased morbidity and
mortality in children with sickle cell disease. Aggressive management of fever, early …