Background/Aims: Alterations in the p16 (CDKN2/MTS-1/INK4A) gene have been implicated
in the tumorigenesis of different human cancers. Recent evidence shows that transcriptional …

Background & Aims: The molecular status of the p16INK4 tumor-suppressor gene has not
been fully elucidated in hepatocellular carcinoma. The aim of this study was to clarify the …

The tumor suppressor gene p16 (CDKN2/MTS-1/INK4A) is an important component of the
cell cycle and inactivation of the gene has been found in a variety of human cancers. In …

Purpose: The tumor suppressor gene p16INK4A is mainly inactivated by an epigenetic
change involving promoter hypermethylation in hepatocarcinogenesis. The possible clinical …

BACKGROUND Inactivation of the tumour suppressor gene p16 (CDKN2/MTS-1/INK4A) and
K-ras mutations are among the most frequent genetic alterations in human malignancies …

Abstract Background and Aim: Hepatocellular carcinoma (HCC) is a common malignancy
worldwide that is highly associated with chronic hepatitis B or C infection and cirrhosis. The …

Abstract BACKGROUND The p16INK4A gene encodes 2 cell cycle regulator proteins, p16
and p14ARF, by alternative splicing. This genetic locus also contains another cell cycle …

AIM: To study the significance of p16 and p15 transcription suppression with
hypermethylation of their genes'5'CpG islands during human hepatocellular carcinogenesis …

We analyzed the p16INK4 status of 6 hepatocellular carcinoma (HCC) cell lines and 32
primary HCC tumors, including 9 early‐stage tumors, to determine whether p16INK4 tumor …

Background: Hepatocellular carcinoma (HCC) is currently the fifth most common solid tumor
worldwide and the third leading cause of cancer related deaths. Several studies have shown …