RGD-modified liposomes targeted to activated platelets as a potential vascular drug delivery system

AS Gupta, G Huang, BJ Lestini… - Thrombosis and …, 2005 - thieme-connect.com
Local drug delivery has become an important treatment modality for the prevention of
thrombotic events following coronary angioplasty. In this study, we investigate the ability of …

In vitro and in vivo platelet targeting by cyclic RGD‐modified liposomes

R Srinivasan, RE Marchant… - Journal of Biomedical …, 2010 - Wiley Online Library
Cell‐selective delivery using ligand‐decorated nanoparticles is a promising modality for
treating cancer and vascular diseases. We are developing liposome nanoparticles surface …

Affinity manipulation of surface-conjugated RGD peptide to modulate binding of liposomes to activated platelets

G Huang, Z Zhou, R Srinivasan, MS Penn… - Biomaterials, 2008 - Elsevier
Platelet adhesion, activation and fibrinogen-mediated aggregation are primary events in
vascular thrombosis and occlusion. An injectable delivery system that can carry …

Platelets directed liposomes for the delivery of streptokinase: development and characterization

B Vaidya, GP Agrawal, SP Vyas - European journal of pharmaceutical …, 2011 - Elsevier
The present study was aimed to study the effect of RGD peptide conjugation on the bio-
distribution behaviour of long circulatory liposomes in the thrombosed rat model. Further …

Cyclic RGD functionalized liposomes encapsulating urokinase for thrombolysis

N Zhang, C Li, D Zhou, C Ding, Y Jin, Q Tian, X Meng… - Acta biomaterialia, 2018 - Elsevier
Thrombosis, a critical event in blood vessels, not only is associated with myocardial
infarction and stroke, but also accounts for considerable morbidity and mortality …

Heteromultivalent liposomal nanoconstructs for enhanced targeting and shear-stable binding to active platelets for site-selective vascular drug delivery

CL Modery, M Ravikumar, TL Wong, MJ Dzuricky… - Biomaterials, 2011 - Elsevier
Activated platelets play multiple roles in vascular diseases. Hence, a delivery vehicle that
can specifically target activated platelets and stay retained under a hemodynamic …

[HTML][HTML] Development of fibrinogen γ‐chain peptide‐coated, adenosine diphosphate‐encapsulated liposomes as a synthetic platelet substitute

Y Okamura, S Takeoka, K Eto, I Maekawa… - Journal of Thrombosis …, 2009 - Elsevier
Summary Background: The dodecapeptide HHLGGAKQAGDV (H12), corresponding to the
fibrinogen γ‐chain carboxy‐terminal sequence (γ400‐411), is a specific binding site of the …

Surface modification of liposomes for selective cell targeting in cardiovascular drug delivery

BJ Lestini, SM Sagnella, Z Xu, MS Shive… - Journal of Controlled …, 2002 - Elsevier
Cardiovascular disease processes such as atherosclerosis, restenosis, and inflammation
are typically localized to discrete regions of the vasculature, affording great opportunity for …

Development and characterization of site specific target sensitive liposomes for the delivery of thrombolytic agents

B Vaidya, MK Nayak, D Dash, GP Agrawal… - International journal of …, 2011 - Elsevier
In recent times, search for potent and highly selective thrombolytic agents with minimal side
effects has become a major area of research. The aim of the present study was to develop …

Liposomes modified with cyclic RGD peptide for tumor targeting

PK Dubey, V Mishra, S Jain, S Mahor… - Journal of drug …, 2004 - Taylor & Francis
Cyclic RGD peptide anchored sterically stabilized liposomes (RGD-SL) were investigated for
selective and preferential presentation of carrier contents at angiogenic endothelial cells …