RGD-modified liposomes targeted to activated platelets as a potential vascular drug delivery system
AS Gupta, G Huang, BJ Lestini… - Thrombosis and …, 2005 - thieme-connect.com
Local drug delivery has become an important treatment modality for the prevention of
thrombotic events following coronary angioplasty. In this study, we investigate the ability of …
thrombotic events following coronary angioplasty. In this study, we investigate the ability of …
In vitro and in vivo platelet targeting by cyclic RGD‐modified liposomes
R Srinivasan, RE Marchant… - Journal of Biomedical …, 2010 - Wiley Online Library
Cell‐selective delivery using ligand‐decorated nanoparticles is a promising modality for
treating cancer and vascular diseases. We are developing liposome nanoparticles surface …
treating cancer and vascular diseases. We are developing liposome nanoparticles surface …
Affinity manipulation of surface-conjugated RGD peptide to modulate binding of liposomes to activated platelets
G Huang, Z Zhou, R Srinivasan, MS Penn… - Biomaterials, 2008 - Elsevier
Platelet adhesion, activation and fibrinogen-mediated aggregation are primary events in
vascular thrombosis and occlusion. An injectable delivery system that can carry …
vascular thrombosis and occlusion. An injectable delivery system that can carry …
Platelets directed liposomes for the delivery of streptokinase: development and characterization
B Vaidya, GP Agrawal, SP Vyas - European journal of pharmaceutical …, 2011 - Elsevier
The present study was aimed to study the effect of RGD peptide conjugation on the bio-
distribution behaviour of long circulatory liposomes in the thrombosed rat model. Further …
distribution behaviour of long circulatory liposomes in the thrombosed rat model. Further …
Cyclic RGD functionalized liposomes encapsulating urokinase for thrombolysis
N Zhang, C Li, D Zhou, C Ding, Y Jin, Q Tian, X Meng… - Acta biomaterialia, 2018 - Elsevier
Thrombosis, a critical event in blood vessels, not only is associated with myocardial
infarction and stroke, but also accounts for considerable morbidity and mortality …
infarction and stroke, but also accounts for considerable morbidity and mortality …
Heteromultivalent liposomal nanoconstructs for enhanced targeting and shear-stable binding to active platelets for site-selective vascular drug delivery
CL Modery, M Ravikumar, TL Wong, MJ Dzuricky… - Biomaterials, 2011 - Elsevier
Activated platelets play multiple roles in vascular diseases. Hence, a delivery vehicle that
can specifically target activated platelets and stay retained under a hemodynamic …
can specifically target activated platelets and stay retained under a hemodynamic …
[HTML][HTML] Development of fibrinogen γ‐chain peptide‐coated, adenosine diphosphate‐encapsulated liposomes as a synthetic platelet substitute
Summary Background: The dodecapeptide HHLGGAKQAGDV (H12), corresponding to the
fibrinogen γ‐chain carboxy‐terminal sequence (γ400‐411), is a specific binding site of the …
fibrinogen γ‐chain carboxy‐terminal sequence (γ400‐411), is a specific binding site of the …
Surface modification of liposomes for selective cell targeting in cardiovascular drug delivery
BJ Lestini, SM Sagnella, Z Xu, MS Shive… - Journal of Controlled …, 2002 - Elsevier
Cardiovascular disease processes such as atherosclerosis, restenosis, and inflammation
are typically localized to discrete regions of the vasculature, affording great opportunity for …
are typically localized to discrete regions of the vasculature, affording great opportunity for …
Development and characterization of site specific target sensitive liposomes for the delivery of thrombolytic agents
In recent times, search for potent and highly selective thrombolytic agents with minimal side
effects has become a major area of research. The aim of the present study was to develop …
effects has become a major area of research. The aim of the present study was to develop …
Liposomes modified with cyclic RGD peptide for tumor targeting
Cyclic RGD peptide anchored sterically stabilized liposomes (RGD-SL) were investigated for
selective and preferential presentation of carrier contents at angiogenic endothelial cells …
selective and preferential presentation of carrier contents at angiogenic endothelial cells …