The cardiovascular actions of serotonin and its antagonists are reviewed with a view to
clarifying whether serotonin has a role in blood pressure control through actions on the …

Hydroxytryptamine (5-HT) contracts ring preparations of rabbit saphenous vein via direct
and indirect components, the latter being-compatible with a “tyramine-like” action at …

In a randomized double-blind study with parallel design involving 20 hypertensive patients,
the antihypertensive activity and effect on platelet function of ketanserin have been …

1 In a previous study, we attempted to verify the classification of 5‐hydroxytryptamine2 (5‐
HT2) receptors in three vascular tissues, by use of the conventional antagonists, ketanserin …

1 Using recently available selective agonists and antagonists we have examined further our
postulate (Apperley et al., 1980) that 5‐hydroxytryptamine (5‐HT) mediates contraction of …

Experiments were designed to determine whether or not ketanserin (R 41 468) antagonizes
the augmentation by 5-hydroxytryptamine of contractions evoked in isolated arteries by non …

Ketanserin is the prototype of a new series, of serotonin antagonists which competitively and
selectively block the 5-HT2 (or $2) receptor. Ketanserin and its analogues antagonize the …

Serotonin is a widely distributed amine, although 95% is found in the enterochromaffin cells
of the gastrointestinal mucosa. Its effects are mediated via a large number of receptors …

Isometric contractions were obtained to 5‐hydroxytryptamine receptor agonists in human
saphenous vein and human coronary artery. Based on the interaction with the 5‐HT2 …

Attempts to correlate 5-hydroxytryptamine (5-HT) binding sites and the receptor mediating 5-
HT-induced contractions in the canine basilar artery (CBA) have led to discrepant claims …