Aims/hypothesis Type 2 diabetes is characterised by islet amyloid and toxic oligomers of
islet amyloid polypeptide (IAPP). We posed the questions,(1) does IAPP toxicity induce an …

Highlights•Mild islet inflammation is present in type 2 diabetes.•Potential triggers include
excess nutrients, islet amyloid and humoral factors.•Anti-inflammatory drugs are of modest …

The toxic effects of human islet amyloid polypeptide (IAPP) on pancreatic islets have been
widely studied. However, much less attention has been paid to the physiologic actions of …

Genome-wide association studies in human type 2 diabetes (T2D) have renewed interest in
the pancreatic islet as a contributor to T2D risk. Chronic low-grade inflammation resulting …

The islet in type 2 diabetes (T2D) shares many features of the brain in protein misfolding
diseases. There is a deficit of β cells with islet amyloid derived from islet amyloid polypeptide …

Aims/hypothesis Amyloid deposition and inflammation are characteristic of islet pathology in
type 2 diabetes. The aim of this study was to determine whether islet amyloid formation is …

OBJECTIVE Cytokines contribute to pancreatic β-cell death in type 1 diabetes. This effect is
mediated by complex gene networks that remain to be characterized. We presently utilized …

Aims/hypothesis Aggregation of islet amyloid polypeptide (IAPP) to form amyloid contributes
to beta cell dysfunction in type 2 diabetes. Human but not non-amyloidogenic rodent IAPP …

Type 2 diabetes (T2D) is characterized by a deficiency in β cell mass, increased β cell
apoptosis, and extracellular accumulation of islet amyloid derived from islet amyloid …

Diabetes involves the death or dysfunction of pancreatic β-cells. Analysis of bulk sequencing
from human samples and studies using in vitro and in vivo models suggest that endoplasmic …