Conformational diseases are caused by mutations altering the folding pathway or final
conformation of a protein. Many conformational diseases are caused by mutations in …

The endoplasmic reticulum (ER) is the site where proteins enter the secretory pathway.
Proteins are translocated into the ER lumen in an unfolded state and require protein …

▪ Abstract In the endoplasmic reticulum (ER), secretory and transmembrane proteins fold into
their native conformation and undergo posttranslational modifications important for their …

The vast majority of proteins that a cell secretes or displays on its surface first enter the
endoplasmic reticulum (ER), where they fold and assemble. Only properly assembled …

Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …

The accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER)
induces a coordinated adaptive program called the unfolded protein response (UPR). The …

In all eukaryotic cells, the endoplasmic reticulum (ER) is an intracellular organelle where
folding and assembly occurs for proteins destined to the extracellular space, plasma …

The endoplasmic reticulum (ER) responds to the accumulation of unfolded proteins in its
lumen (ER stress) by activating intracellular signal transduction pathways—cumulatively …

In eukaryotic cells, the endoplasmic reticulum (ER) is a membrane-enclosed interconnected
organelle responsible for the synthesis, folding, modification, and quality control of …

The endoplasmic reticulum (ER) is a central organelle for protein biosynthesis, folding, and
traffic. Perturbations in ER homeostasis create a condition termed ER stress and lead to …