Large-scale analysis of post-translational modifications in E. coli under glucose-limiting conditions

CW Brown, V Sridhara, DR Boutz, MD Person… - Bmc Genomics, 2017 - Springer
Background Post-translational modification (PTM) of proteins is central to many cellular
processes across all domains of life, but despite decades of study and a wealth of genomic …

Beyond gene expression: the impact of protein post-translational modifications in bacteria

JA Cain, N Solis, SJ Cordwell - Journal of proteomics, 2014 - Elsevier
The post-translational modification (PTM) of proteins plays a critical role in the regulation of
a broad range of cellular processes in eukaryotes. Yet their role in governing similar systems …

Regulatory potential of post-translational modifications in bacteria

C Grangeasse, J Stülke, I Mijakovic - Frontiers in microbiology, 2015 - frontiersin.org
Bacteria are often viewed as simple organisms, with very basic and robust cellular
regulation, optimized for rapid growth. While they certainly fit that description, bacteria also …

Characterizing posttranslational modifications in prokaryotic metabolism using a multiscale workflow

E Brunk, RL Chang, J Xia, H Hefzi… - Proceedings of the …, 2018 - National Acad Sciences
Understanding the complex interactions of protein posttranslational modifications (PTMs)
represents a major challenge in metabolic engineering, synthetic biology, and the …

Post-translational protein acetylation: an elegant mechanism for bacteria to dynamically regulate metabolic functions

DG Christensen, X Xie, N Basisty, J Byrnes… - Frontiers in …, 2019 - frontiersin.org
Post-translational modifications (PTM) decorate proteins to provide functional heterogeneity
to an existing proteome. The large number of known PTMs highlights the many ways that …

Evolution and functional cross‐talk of protein post‐translational modifications

P Beltrao, P Bork, NJ Krogan… - Molecular systems …, 2013 - embopress.org
Protein post‐translational modifications (PTM s) allow the cell to regulate protein activity and
play a crucial role in the response to changes in external conditions or internal states …

TagGraph reveals vast protein modification landscapes from large tandem mass spectrometry datasets

A Devabhaktuni, S Lin, L Zhang, K Swaminathan… - Nature …, 2019 - nature.com
Although mass spectrometry is well suited to identifying thousands of potential protein post-
translational modifications (PTMs), it has historically been biased towards just a few. To …

A glimpse into the modulation of post-translational modifications of human-colonizing bacteria

PAD Bastos, JP da Costa, R Vitorino - Journal of proteomics, 2017 - Elsevier
Protein post-translational modifications (PTMs) are a key bacterial feature that holds the
capability to modulate protein function and responses to environmental cues. Until recently …

The next level of complexity: crosstalk of posttranslational modifications

AS Venne, L Kollipara, RP Zahedi - Proteomics, 2014 - Wiley Online Library
Beside gene expression and translational control, which are relatively slow, PTM of proteins
represents the major level of regulation, from very fast and reversible to slow or irreversible …

Modification‐specific proteomics: strategies for characterization of post‐translational modifications using enrichment techniques

Y Zhao, ON Jensen - Proteomics, 2009 - Wiley Online Library
More than 300 different types of protein post‐translational modifications (PTMs) have been
described, many of which are known to have pivotal roles in cellular physiology and …