Objective Augmenting and switching antidepressant medications are the 2 most common
next-step strategies for depressed patients failing initial medication treatment. These …

Only 30% of patients with major depressive disorder achieve remission with initial treatment,
and many patients with depression undergo serial treatment trials to improve response …

Abstract The Sequenced Treatment Alternatives to Relieve Depression trial enrolled
outpatients with nonpsychotic major depressive disorder treated prospectively in a series of …

Objective Antidepressant switch is a commonly used strategy in the absence of an adequate
response, but optimum timing is not well established. We compared the efficacy of an early …

Objective: This report describes the participants and compares the acute and longer-term
treatment outcomes associated with each of four successive steps in the Sequenced …

Objective: This report describes the participants and compares the acute and longer-term
treatment outcomes associated with each of four successive steps in the Sequenced …

Importance Less than one-third of patients with major depressive disorder (MDD) achieve
remission with their first antidepressant. Objective To determine the relative effectiveness …

STAR* D is a multisite, prospective, randomized, multistep clinical trial of outpatients with
nonpsychotic major depressive disorder. The study compares various treatment options for …

STAR* D represents a 7-year effort by literally hundreds of people and thousands of
patients. Future reports will 1) compare longer-term outcomes of the various randomized …

Objective: Treatment of major depressive disorder typically entails implementing treatments
in a stepwise fashion until a satisfactory outcome is achieved. This study sought to identify …