This study is to research the quantitative structure–permeability relationship of 20 drugs
having similar structure. Permeability was determined by using the Caco-2 cell in vitro …

Permeability (Pe) is one of the key determinants in the absorption, distribution, metabolism,
excretion/pharmacokinetics (ADME/PK) of drugs and their metabolites. Predictions of …

The Biopharmaceutics Classification System (BCS), based on the aqueous solubility and
intestinal permeability of a drug substance, has been widely used to predict the extent of …

Background: Two main factors, which have an influence on oral absorption from solid,
immediate release dosage form, are solubility and permeability. These are considered the …

Purpose. To develop a quantitative biopharmaceutics drug classification system (QBCS)
based on fundamental parameters controlling rate and extent of absorption. Methods. A …

Hydrogen bonding has been identified as an important parameter for describing drug
permeability. Recently, we derived models for predicting intestinal permeability using the …

Objectives The aim of this study was (1) to determine how closely physiologically based
pharmacokinetic (PBPK) models can predict oral bioavailability using a priori knowledge of …

The purpose of the present study was to examine the relevancy of the high throughput
solubility assay and permeability assay to the biopharmaceutics classification system (BCS) …

Experimental models of permeability in animals, excised tissues, cell monolayers, and
artificial membranes are important during drug discovery and development as permeability …

ABSTRACT Biopharmaceutics Classification System and Biopharmaceutics Drug
Distribution Classification System are complimentary, not competing, classification systems …