Purpose: The biopharmaceutical classification system has been developed to provide a
scientific approach for classifying drug compounds based on their dose/solubility ratio and …

Purpose: To develop a computational method to rapidly evaluate human intestinal
absorption, one of the drug properties included in the term ADME (Absorption, Distribution …

The human intestinal absorption (HIA) of drugs was studied using a topological sub-
structural approach (TOPS-MODE). The drugs were divided into three classes according to …

Caco-2 cells are currently the most used in vitro tool for prediction of the potential oral
absorption of new drugs. The existence of computational models based on this data may …

Abstract The Biopharmaceutics Classification System (BCS) classifies pharmaceutical
compounds based on their aqueous solubility and intestinal permeability. The BCS Class III …

Purpose The objective was to establish in vitro passive permeability (P e) vs in vivo fraction
absorbed (fa)-relationships for each passage through the human intestine, liver, renal tubuli …

Oral dosing is the most common method of drug administration, and final plasma
concentrations of the drug depend upon its bioavailability. In the current study, a quantitative …

The main objective of this work was to investigate in-silico predictions of physicochemical
properties, in order to guide oral drug development by provisional biopharmaceutics …

In recent years, the pharmaceutical sector has been viewed as one of the most revenue-
generating fields which primarily deals with all the activities ranging from approving …

The vast majority of marketed drugs are orally administrated. As such, drug absorption is
one of the important drug metabolism and pharmacokinetics parameters that should be …