The immune system has evolved complex effector mechanisms to protect the host against a
diversity of pathogenic organisms and regulatory adaptations that can curtail pathological …

At the present time, regulatory T cells (Tregs) are an integral part of immunology but the
route from discovery of “suppressive” lymphocytes in the 1980s to the current established …

The inflammatory response to transformed cells forms the cornerstone of natural or
therapeutically induced protective immunity to cancer. Regulatory T (Treg) cells are known …

Importance of the field: The active suppression of immune responses against tumor is a
major barrier to the likely success of cancer immunotherapy. There is now compelling …

Regulatory T (Treg) cells are found at elevated densities in many human cancers and are
thought to be a major barrier to the generation of robust antitumor T cell responses. In this …

Over the last years a number of reports have described elevated numbers of regulatory T
(Treg) cells inside of tumors, in close proximity of the tumor, draining lymph nodes and also …

Regulatory T (Treg) cells play a crucial role in maintaining peripheral tolerance and
preventing autoimmunity. However, they also represent a major barrier to effective antitumor …

Regulatory T cells (Tregs) are important members of the immune system regulating the host
responses to infection and neoplasms. Tregs prevent autoimmune disorders by protecting …

There has been an explosion of literature focusing on the role of regulatory T (Treg) cells in
cancer immunity. It is becoming increasingly clear that Treg cells play an active and …

Regulatory T (Treg) cells suppress abnormal/excessive immune responses to self‐and
nonself‐antigens to maintain immune homeostasis. In tumor immunity, Treg cells are …