Mitochondrial integrity relies on homotypic fusion between adjacent outer membranes,
which is mediated by large GTPases called mitofusins. The regulation of this process …

Mitofusins, conserved dynamin-related GTPases in the mitochondrial outer membrane,
mediate the fusion of mitochondria. Here, we demonstrate that the activity of the mitofusin …

The mitochondrion is a dynamic membranous network whose morphology is conditioned by
the equilibrium between ongoing fusion and fission of mitochondrial membranes. In the …

The ability of cells to respire requires that mitochondria undergo fusion and fission of their
outer and inner membranes. The means by which levels of fusion 'machinery'components …

Mitofusins are large GTPases that trigger fusion of mitochondrial outer membranes. Similarly
to the human mitofusin Mfn2, which also tethers mitochondria to the endoplasmic reticulum …

Mitofusins, Fzo1 in yeast and Mfn1 and Mfn2 in mammals, are ubiquitylated and this post-
translational modification has both positive and negative consequences on mitochondrial …

Mitofusins are large GTPases essential for mitochondrial fusion. In this issue, Anton et
al.(2013) report that two independent pathways of ubiquitylation/deubiquitylation control …

Defects in mitochondrial fusion are at the base of many diseases. Mitofusins power
membrane-remodeling events via self-interaction and GTP hydrolysis. However, how exactly …

Dynamin-related GTPase proteins (DRPs) are main players in membrane remodelling.
Conserved DRPs called mitofusins (Mfn1/Mfn2/Fzo1) mediate the fusion of mitochondrial …

Mitochondrial fusion is a highly coordinated process that mixes and unifies the mitochondrial
compartment for normal mitochondrial functions and mitochondrial DNA inheritance …