Lymphatic Dysregulation in Patients With Heart Failure: JACC Review Topic of the Week

M Fudim, HM Salah, J Sathananthan, M Bernier… - Journal of the American …, 2021 - jacc.org
The lymphatic system is an integral part of the circulatory system and plays an important role
in the volume homeostasis of the human body. The complex anatomy and physiology paired …

The cardiac lymphatic system stimulates resolution of inflammation following myocardial infarction

JM Vieira, S Norman, CV Del Campo… - The Journal of …, 2018 - Am Soc Clin Investig
Myocardial infarction (MI) arising from obstruction of the coronary circulation engenders
massive cardiomyocyte loss and replacement by non-contractile scar tissue, leading to …

Cardiac macrophage subsets differentially regulate lymphatic network remodeling during pressure overload

M Bizou, R Itier, M Majdoubi, D Abbadi, E Pichery… - Scientific Reports, 2021 - nature.com
The lymphatic network of mammalian heart is an important regulator of interstitial fluid
compartment and immune cell trafficking. We observed a remodeling of the cardiac …

Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration

D Gancz, BC Raftrey, G Perlmoter, R Marín-Juez… - Elife, 2019 - elifesciences.org
In recent years, there has been increasing interest in the role of lymphatics in organ repair
and regeneration, due to their importance in immune surveillance and fluid homeostasis …

Pathophysiology of the Lymphatic System in Patients With Heart Failure: JACC State-of-the-Art Review

M Itkin, SG Rockson, D Burkhoff - Journal of the American College of …, 2021 - jacc.org
The removal of interstitial fluid from the tissues is performed exclusively by the lymphatic
system. Tissue edema in congestive heart failure occurs only when the lymphatic system …

Heterogeneity in the lymphatic vascular system and its origin

MH Ulvmar, T Mäkinen - Cardiovascular research, 2016 - academic.oup.com
Lymphatic vessels have historically been viewed as passive conduits for fluid and immune
cells, but this perspective is increasingly being revised as new functions of lymphatic vessels …

Promoting lymphangiogenesis and lymphatic growth and remodeling to treat cardiovascular and metabolic diseases

X Liu, K Cui, H Wu, KS Li, Q Peng, D Wang… - … , and vascular biology, 2023 - Am Heart Assoc
Lymphatic vessels are low-pressure, blind-ended tubular structures that play a crucial role in
the maintenance of tissue fluid homeostasis, immune cell trafficking, and dietary lipid uptake …

Diagnosis and management of lymphatic disorders in congenital heart disease

B Kelly, S Mohanakumar, VE Hjortdal - Current Cardiology Reports, 2020 - Springer
Abstract Purpose of Review Lymphatic disorders have received an increasing amount of
attention over the last decade. Sparked primarily by improved imaging modalities and the …

Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart

TJ Cahill, X Sun, C Ravaud, C Villa del Campo… - …, 2021 - journals.biologists.com
Macrophages are components of the innate immune system with key roles in tissue
inflammation and repair. It is now evident that macrophages also support organogenesis …

[PDF][PDF] A second heart field-derived vasculogenic niche contributes to cardiac lymphatics

G Lioux, X Liu, S Temiño, M Oxendine, E Ayala… - Developmental cell, 2020 - cell.com
The mammalian heart contains multiple cell types that appear progressively during
embryonic development. Advance in determining cardiac lineage diversification has often …