Cardiac lymphatics are heterogeneous in origin and respond to injury
L Klotz, S Norman, JM Vieira, M Masters, M Rohling… - Nature, 2015 - nature.com
The lymphatic vasculature is a blind-ended network crucial for tissue-fluid homeostasis,
immune surveillance and lipid absorption from the gut. Recent evidence has proposed an …
immune surveillance and lipid absorption from the gut. Recent evidence has proposed an …
Enhancement of cardiac lymphangiogenesis by transplantation of CD34+VEGFR-3+ endothelial progenitor cells and sustained release of VEGF-C
H Zhang, Y Wang, Y Tan, H Wang, P Tao… - Basic Research in …, 2019 - Springer
Impairment of cardiac lymphatic vessels leads to cardiac lymphedema. Recent studies have
suggested that stimulation of lymphangiogenesis may reduce cardiac lymphedema …
suggested that stimulation of lymphangiogenesis may reduce cardiac lymphedema …
The lymphatic vasculature: development and role in shaping immunity
KL Betterman, NL Harvey - Immunological Reviews, 2016 - Wiley Online Library
The lymphatic vasculature is an integral component of the immune system. Lymphatic
vessels are a key highway via which immune cells are trafficked, serving not simply as a …
vessels are a key highway via which immune cells are trafficked, serving not simply as a …
Lymphatic vessels in health and disease
The lymphatic vasculature plays vital roles in tissue fluid balance, immune defense,
metabolism, and cancer metastasis. In adults, lymphatic vessel formation and remodeling …
metabolism, and cancer metastasis. In adults, lymphatic vessel formation and remodeling …
Lessons of vascular specialization from secondary lymphoid organ lymphatic endothelial cells
S Arroz-Madeira, T Bekkhus, MH Ulvmar… - Circulation …, 2023 - Am Heart Assoc
Secondary lymphoid organs, such as lymph nodes, harbor highly specialized and
compartmentalized niches. These niches are optimized to facilitate the encounter of naive …
compartmentalized niches. These niches are optimized to facilitate the encounter of naive …
[HTML][HTML] A single-cell transcriptional roadmap of the mouse and human lymph node lymphatic vasculature
Single-cell transcriptomics promise to revolutionize our understanding of the vasculature.
Emerging computational methods applied to high-dimensional single-cell data allow …
Emerging computational methods applied to high-dimensional single-cell data allow …
Genetic blockade of lymphangiogenesis does not impair cardiac function after myocardial infarction
TCS Keller, L Lim, SV Shewale… - The Journal of …, 2021 - Am Soc Clin Investig
In recent decades, treatments for myocardial infarction (MI), such as stem and progenitor cell
therapy, have attracted considerable scientific and clinical attention but failed to improve …
therapy, have attracted considerable scientific and clinical attention but failed to improve …
The lymphatic vasculature in disease
K Alitalo - Nature medicine, 2011 - nature.com
Blood vessels form a closed circulatory system, whereas lymphatic vessels form a one-way
conduit for tissue fluid and leukocytes. In most vertebrates, the main function of lymphatic …
conduit for tissue fluid and leukocytes. In most vertebrates, the main function of lymphatic …
The lymphatic system: integral roles in immunity
The lymphatic vasculature is not considered a formal part of the immune system, but it is
critical to immunity. One of its major roles is in the coordination of the trafficking of antigen …
critical to immunity. One of its major roles is in the coordination of the trafficking of antigen …
Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension
LJ Song, X Chen, TA Swanson, B LaViolette, J Pang… - Elife, 2020 - elifesciences.org
The lymphatic vasculature is involved in the pathogenesis of acute cardiac injuries, but little
is known about its role in chronic cardiac dysfunction. Here, we demonstrate that …
is known about its role in chronic cardiac dysfunction. Here, we demonstrate that …