Traumatic brain injuries (TBI) and stroke are major causes of morbidity and mortality in both
developing and developed countries. The complex and heterogeneous pathophysiology of …

High level of detrimental factors including reactive oxygen species (ROS) and inflammatory
cytokines accumulated in the infarct core and their erosion to salvageable penumbra are key …

Stroke is a prevalent global acute cerebrovascular condition, with ischaemic stroke being
the most frequently occurring type. After a stroke, neutrophils accumulate in the brain and …

Stroke is one of the most prevalent diseases worldwide caused primarily by a thrombotic
vascular occlusion that leads to cell death. To date, t-PA (tissue-type plasminogen activator) …

Precise and efficient regulation of microglia is vital for ischemic stroke therapy and
prognosis. The infiltration of neutrophils into the brain provides opportunities for regulatory …

Stroke is a threatening cerebrovascular disease caused by thrombus with high morbidity
and mortality rates. Neutrophils are the first to be recruited in the brain after stroke, which …

Cerebral ischemic injury, one of the leading causes of morbidity and mortality worldwide,
triggers various central nervous system (CNS) diseases, including acute ischemic stroke …

Brain inflammation is regarded as one of the leading causes that aggravates secondary
brain injury and hinders the prognosis of ischemic stroke. After ischemic stroke, high …

Neutrophils have key roles in ischemic brain injury, thrombosis, and atherosclerosis. As
such, neutrophils are of great interest as targets to treat and prevent ischemic stroke. After …

The treatment of reperfusion injury after ischemic stroke remains unsatisfactory since the
blood‐brain barrier (BBB) prevents most neuroprotective agents from entering the brain …