Upon invasive bacterial infection of colonic epithelium, host cells induce several types of cell
death to eliminate pathogens. For instance, necroptosis is a RIPK‐dependent lytic cell death …

Caspase-mediated inflammatory cell death acts as an intrinsic defense mechanism against
infection. Bacterial pathogens deploy countermeasures against inflammatory cell death, but …

Although induction of host cell death is a pivotal step during bacteria-induced gastroenteritis,
the molecular regulation remains to be fully characterized. To expand our knowledge, we …

Highlights•Host cell death is an immune defense against bacterial infection.•Shigella
circumvents epithelial cell death to maintain its replicative niche.•Shigella utilizes specific …

The cytosolic appearance and propagation of bacteria cause overwhelming cellular stress
responses that induce apoptosis under normal conditions. Therefore, successful bacterial …

Pyroptosis is an inflammatory form of cell death induced upon recognition of invading
microbes. During an infection, pyroptosis is enhanced in interferon-gamma-exposed cells …

Programmed cell death contributes to host defense against pathogens. To investigate the
relative importance of pyroptosis, necroptosis, and apoptosis during Salmonella infection …

Shigella flexneri, a cytosol-invasive gram-negative pathogen, deploys an array of type III-
secreted effector proteins to evade host cell defenses. Caspase-11 and its human ortholog …

Bacteria of the genus Shigella cause shigellosis, a severe gastrointestinal disease driven by
bacterial colonization of colonic intestinal epithelial cells. Vertebrates have evolved …

Cell death signalling pathways contribute to tissue homeostasis and provide innate
protection from infection. Adaptor proteins such as receptor-interacting serine/threonine …