The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity

Q Wu, B Ning, J Xuan, Z Ren, L Guo, MS Bryant - Toxicology letters, 2016 - Elsevier
Amiodarone is a widely used potent antiarrhythmic for the treatment of cardiac disease;
however, its use is often discontinued due to numerous adverse effects, including …

Rapidly fatal acute amiodarone hepatitis occurring in the context of multiple organ failure

RJ MacFadyen, TJ Palmer… - International …, 2003 - internationaljournalofcardiology.com
Amiodarone remains the agent of choice for the 80 mmHg and clinical and radiological
evidence of management of atrial fibrillation in unstable patients fluid overload. He was …

[PDF][PDF] Amiodarone‐induced hepatic phospholipidosis: a morphological alteration independent of pseudoalcoholic liver disease

B Guigui, S Perrot, JP Berry, J Fleury‐Feith… - …, 1988 - Wiley Online Library
In order to study the relationship between amiodarone‐induced hepatic phospholipidosis
and liver disease, liver biopsies obtained from 13 patients treated with amiodarone for 4 …

[HTML][HTML] Amiodarone-induced hepatotoxicity—quantitative measurement of iodine density in the liver using dual-energy computed tomography: Three case reports

HJ Lv, HW Zhao - World Journal of Clinical Cases, 2020 - ncbi.nlm.nih.gov
BACKGROUND Amiodarone is the drug most commonly used to manage arrhythmias. Long-
term amiodarone administration causes hepatotoxicity due to iodine accumulation in the …

Analysis of increased hepatic density during chronic amiodarone therapy

K Hirakawa, K Abe, Y Ayabe… - Nihon Igaku Hoshasen …, 2003 - europepmc.org
Amiodarone is an amphiphilic, iodinated, benzofuran derivative that is known to be effective
for refractory ventricular tachyarrhythmia. Amiodarone also is known to cause a variety of …

[引用][C] Amiodarone‐associated cirrhosis with hepatic and lymph node granulomas

RF Harrison, E Elias - Histopathology, 1993 - Wiley Online Library
Discussion The radiological, macroscopic and histological features of this case are typical of
a bizarre parosteal osteochondromatous proliferation. This tumour typically occurs on the …

Use of population modeling to define rational monitoring of amiodarone hepatic effects

PT Pollak, SL Shafer - Clinical Pharmacology & Therapeutics, 2004 - Wiley Online Library
Background Amiodarone causes hepatotoxicity in experimental models, but in humans, the
relationships between drug administration, serum concentrations, markers of liver function …

Granular cells as a marker of early amiodarone hepatotoxicity: a pathological and analytical study.

NA Shepherd, AM Dawson, PR Crocker… - Journal of clinical …, 1987 - jcp.bmj.com
Two contrasting cases of amiodarone hepatotoxicity are described. In one, perivenular
collections of swollen cells, probably macrophages, with granular cytoplasm in an otherwise …

Increased Density of the Liver and Amiodarone‐Associated Phospholipidosis

S Kojima, S Kojima, H Ueno, M Takeya… - … research and practice, 2009 - Wiley Online Library
This is a case report in which a 60‐year‐old man who suffered from ventricular tachycardia
with dilated cardiomyopathy was prescribed amiodarone. After taking amiodarone, liver …

[PDF][PDF] Oral Amiodarone-induced Liver Injury with Gamma Glutamyl Transferase Elevation: A Case Report

MZ Kocak, N Ilhan, S Ozsari, K Fidan - Eurasian Journal of Medicine and …, 2018 - ejmo.org
Amiodarone-induced hepatotoxicity varies from asymptomatic serum aminotransferase
elevation to severe liver disease. Aspartate aminotransferase, alanine aminotransferase …