DNA supercoiling is an inherent consequence of twisting DNA and is critical for regulating
gene expression and DNA replication. However, DNA supercoiling at a genomic scale in …

Supercoiling is a fundamental property of DNA and chromatin. It is modulated by
polymerase and topoisomerase activities and, through regulated constraint, by …

Transcription has the capacity to mechanically modify DNA topology, DNA structure and
nucleosome arrangement. Resulting from ongoing transcription, these modifications in turn …

Disruptions in chromatin structure are necessary for the regulation of eukaryotic genomes,
from remodelling of nucleosomes at the base pair level through to large-scale chromatin …

Chromatin folding contributes to the regulation of genomic processes such as gene activity.
Existing conformation capture methods characterize genome topology through analysis of …

Eukaryotic genomes are organized into condensed, heterogeneous chromatin fibers
throughout much of the cell cycle. Here we describe recent studies indicating that even …

Entangling and twisting of cellular DNA (ie, supercoiling) are problems inherent to the
helical structure of double-stranded DNA. Supercoiling affects transcription, DNA replication …

The different cell types of an organism share the same DNA, but during cell differentiation
their genomes undergo diverse structural and organizational changes that affect gene …

The chromatin fiber folds into loops, but the mechanisms controlling loop extrusion are still
poorly understood. Using super-resolution microscopy, we visualize that loops in intact …

Mammalian genomes encode genetic information in their linear sequence, but appropriate
expression of their genes requires chromosomes to fold into complex three-dimensional …