During embryogenesis, epithelial organization is the prerequisite for organogenesis, in
particular, for establishing the tubular structure. Recent studies provided hints about …

The HAND2 transcriptional regulator controls cardiac development, and we uncover
additional essential functions in the endothelial to mesenchymal transition (EMT) underlying …

Interventricular septum (IVS) formation is one of the key events in the development of a four-
chambered heart. We previously showed that the basic helix–loop–helix transcription factor …

Rationale: The basic helix–loop–helix (bHLH) transcription factors Hand1 and Hand2 are
essential for embryonic development. Given their requirement for cardiogenesis, it is …

The basic-helix-loop-helix (bHLH) transcription factor Hand2 plays critical roles during
cardiac morphogenesis via expression and function within myocardial, neural crest, and …

Molecular mechanisms for the dorso-ventral patterning and interventricular septum
formation in the embryonic heart are unknown. To investigate a role of Hand1/eHAND in …

The precise origins of myocardial progenitors and their subsequent contribution to the
developing heart has been an area of considerable activity within the field of cardiovascular …

The cardiac neural crest (cNC) lineage plays key roles in heart development by directly
contributing to heart structures and regulating development of other heart lineages. The …

Embryonic heart formation requires the production of an appropriate number of
cardiomyocytes; likewise, cardiac regeneration following injury relies upon the recovery of …

The transcription factor HAND2 plays essential roles during cardiogenesis. Hand2
endocardial deletion (H2CKO) results in tricuspid atresia or double inlet left ventricle with …