There are clear links between chronic inflammation and cancer; strong epidemiological and
genetic evidence indicates that inflammation can drive tumour progression, and more-recent …

Cytokines are secreted or otherwise released polypeptide factors that exert autocrine and/or
paracrine actions, with most cytokines acting in the immune and/or hematopoietic system …

Interleukins and associated cytokines serve as the means of communication for innate and
adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a …

In-depth knowledge of cancer molecular and cellular mechanisms have revealed a strong
regulation of cancer development and progression by the inflammation which orchestrates …

Up to 20% of all cancers arise in association with chronic inflammation and most, if not all,
solid tumours contain inflammatory infiltrates. Immune cells have a broad impact on tumour …

Inflammation is a process to protect the host against infection and danger signals. However,
many pathologic conditions, including autoimmune diseases, are sustained by perpetual …

In reviewing some of the mechanisms whereby cytokine effects are inhibited or blocked, this
chapter has illustrated that the cytokine network is truly self-regulating. Exaggerated effects …

Chronic infections, obesity, alcohol, tobacco, radiation, environmental pollutants, and high-
calorie diet have been recognized as major risk factors for the most common types of cancer …

Cytokines bind to specific receptors on target cells to activate intracellular signaling
pathways that control diverse cellular functions, such as proliferation, differentiation …

Over the past decades the notion of 'inflammation'has been extended beyond the original
hallmarks of rubor (redness), calor (heat), tumor (swelling) and dolor (pain) described by …