Forced hepatic overexpression of CEACAM1 curtails diet-induced insulin resistance
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin
sensitivity by promoting hepatic insulin clearance. Liver-specific inactivation or global null …
sensitivity by promoting hepatic insulin clearance. Liver-specific inactivation or global null …
[HTML][HTML] Reduced hepatic carcinoembryonic antigen-related cell adhesion molecule 1 level in obesity
G Heinrich, HT Muturi, K Rezaei, QY Al-Share… - Frontiers in …, 2017 - frontiersin.org
Impairment of insulin clearance is being increasingly recognized as a critical step in the
development of insulin resistance and metabolic disease. The carcinoembryonic antigen …
development of insulin resistance and metabolic disease. The carcinoembryonic antigen …
[HTML][HTML] Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis [S]
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin
sensitivity by promoting hepatic insulin clearance and mediating suppression of fatty acid …
sensitivity by promoting hepatic insulin clearance and mediating suppression of fatty acid …
[HTML][HTML] Liver-specific reconstitution of CEACAM1 reverses the metabolic abnormalities caused by its global deletion in male mice
L Russo, HT Muturi, HE Ghadieh, SS Ghanem… - Diabetologia, 2017 - Springer
Aims/hypothesis The carcinoembryonic antigen-related cell adhesion molecule 1
(CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1−/−) or with liver …
(CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1−/−) or with liver …
[HTML][HTML] Loss of hepatic CEACAM1: a unifying mechanism linking insulin resistance to obesity and non-alcoholic fatty liver disease
G Heinrich, HE Ghadieh, SS Ghanem… - Frontiers in …, 2017 - frontiersin.org
The pathogenesis of human non-alcoholic fatty liver disease (NAFLD) remains unclear, in
particular in the context of its relationship to insulin resistance and visceral obesity. Work on …
particular in the context of its relationship to insulin resistance and visceral obesity. Work on …
[HTML][HTML] Hepatic CEACAM1 over-expression protects against diet-induced fibrosis and inflammation in white adipose tissue
SG Lester, L Russo, SS Ghanem, SS Khuder… - Frontiers in …, 2015 - frontiersin.org
CEACAM1 promotes insulin extraction, an event that occurs mainly in liver. Phenocopying
global Ceacam1 null mice (Cc1–/–), C57/BL6J mice fed a high-fat (HF) diet exhibited …
global Ceacam1 null mice (Cc1–/–), C57/BL6J mice fed a high-fat (HF) diet exhibited …
Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism
AM DeAngelis, G Heinrich, T Dai, TA Bowman… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Liver-specific inactivation of carcinoembryonic antigen-related cell adhesion
molecule 1 (CEACAM1) by a dominant-negative transgene (l-SACC1 mice) impaired insulin …
molecule 1 (CEACAM1) by a dominant-negative transgene (l-SACC1 mice) impaired insulin …
Carcinoembryonic antigen-related cell adhesion molecule 2 controls energy balance and peripheral insulin action in mice
G Heinrich, S Ghosh, AM DeAngelis… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: The carcinoembryonic antigen-related cell adhesion molecule 1
(CEACAM1) is a transmembrane glycoprotein with pleotropic functions, including clearance …
(CEACAM1) is a transmembrane glycoprotein with pleotropic functions, including clearance …
Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis
HE Ghadieh, L Russo, HT Muturi, SS Ghanem… - Metabolism, 2019 - Elsevier
Background CEACAM1 regulates insulin sensitivity by promoting insulin clearance.
Accordingly, global C57BL/6J. Cc1−/− null mice display hyperinsulinemia due to impaired …
Accordingly, global C57BL/6J. Cc1−/− null mice display hyperinsulinemia due to impaired …
Ceacam1 deletion causes vascular alterations in large vessels
SM Najjar, KJ Ledford, SL Abdallah… - American Journal …, 2013 - journals.physiology.org
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes hepatic
insulin clearance and endothelial survival. However, its role in the morphology of …
insulin clearance and endothelial survival. However, its role in the morphology of …