There is a pharmacokinetic interaction between digoxin and diazepam that increases the
elimination half-life of digoxin. It may be due to a reduction of digoxin tissue concentrations …

Methods Bound and unbound digoxin plasma levels were determined in-vitro, in a control
human plasma containing 2.5 x 1CW M (2 ng ml-1) of digoxin to which 1 and 3 pg ml-1 were …

Recent studies have shown a significant increase in plasma digoxin concentration during
verapamil treatment. This phenomenon has been attributed in part to reduced renal …

The interaction between digoxin and verapamil was studied in six patients (mean age±SD,
61±5 years) with chronic atrial fibrillation. The effects of adding verapamil (240 mg/day) on …

Verapamil has been demonstrated to inhibit the elimination of digoxin and to increase its
steady state plasma level by 60–80%. Animal studies suggest that verapamil abolishes the …

Verapamil and digoxin are often used in combination and clinical experience suggests that
verapamil may increase digoxin toxicity. We have explored the effects of verapamil upon …

Digoxin has been associated with a variety of drug interactions. Studies in our laboratory
indicate that single doses of prazosin may alter plasma steady-state digoxin levels. Adult …

Of the several glycosides available for treating heart disease, digoxin has found most favour
in Britain. All these drugs have a narrow therapeutic index, and intoxication occurs in 10 …

Verapamil and digoxin are frequently used in combination, and clinical experience suggests
that verapamil may increase digoxin toxicity. We have investigated the influence of …

To explore a possible interaction between digoxin and verapamil, a single‐dose kinetic
study of digoxin was performed and then repeated after 10 days of verapamil treatment in …