The binding of the cardiac glycoside digoxin by the serum proteins has been studied by
dialysis, electrophoresis and gel filtration. It was found in vitro that digoxin is located entirely …

The effect of oral amlodipine on steady-state digoxin concentrations and renal clearance
was studied in 21 healthy male subjects. After 2-week digitalization (digoxin, 0.375 mg/day) …

Tissue distribution and left ventricular (LV) effects of digoxin were studied after intravenous
administration of low and high doses to dogs. LV dP/dt was increased by 0.03 mg/kg digoxin …

The extent and time course of the reversal of digoxin-induced inotropy by digoxin-specific
antibodies and their Fab fragments were studied in seven conscious dogs instrumented with …

The influence of oral amiodarone treatment on the blood and tissue concentrations of
digoxin was investigated in the anaesthetized rat by use of unlabelled and [3H]-digoxin. 2 …

QUINIDINE causes a rise in serum steady-state concentrations of digoxin1 2 3 4 5 and
reduces both renal and nonrenal clearances of digoxin. 6 7 8 A redistribution of digoxin from …

It soon becomes apparent to those who use cardiac glycosides clinically that the relation
between the amount of drug administered and the therapeutic effect is highly variable. The …

ABSTRACT Gibson, Thomas P. and Antonio P. Quintanilla: The renal clearance of digoxin is
dependent upon the serum digoxin concentration. J. Pharmacol. Exp. Ther. 21 5: 681-684 …

Nine healthy male volunteers received single 0.5, 1.0, and 1.5 mg. doses of intravenous
digoxin in a randomized three-way crossover study. Multiple venous blood samples were …

With a modified, precise 86Rbmethodplasma digoxin concentration was estimated
inpatients with atrialfibrillation. They received successively increasing digoxin dosesuntil …