Abstract The PI3K/Akt/mTOR (phosphatidylinositol 3 kinase/Akt/mammalian target of
rapamycin) signalling pathway is an established driver of oncogenic activity in human …

Aberrant activation of the PI3K/Akt/mTOR pathway is found in many types of cancer and thus
plays a major role in breast cancer cell proliferation and anti-cancer drug resistance. The …

Activation of the phosphoinositide 3 kinase (PI3K)/Akt/mammalian target of rapamycin
(mTOR) pathway is common in breast cancer. There is preclinical data to support inhibition …

Abstract The PI3K/Akt/mTOR pathway plays a role in various oncogenic processes in breast
cancer and key pathway aberrations have been identified which drive the different molecular …

Simple Summary PI3K signaling pathway plays an essential role in many cellular processes
and is frequently altered in breast cancer, leading to increased tumor growth and reduced …

The PI3K/Akt/mTOR signaling pathway is involved in the inhibition of tumor cell apoptosis,
the promotion of cell survival, cell cycle regulation, tumor angiogenesis, invasion, and …

BACKGROUND: Identification and validation of biomarkers is increasingly important for the
integration of novel targeted agents in the treatment of cancer. The phosphatidylinositol 3 …

Breast cancer is one of the most prevalent and devastating malignant diseases in women
worldwide. Fortunately, while breast cancer incidence is still increasing, its death rate is …

Breast cancer (BC) is the most commonly diagnosed cancer in women. The PI3K/AKT/mTOR
pathway is among the most frequently dysregulated pathways in patients with BC. The …

The phosphoinositide 3 kinase (PI3K)/Akt/mammalian (or mechanistic) target of rapamycin
(mTOR) pathway is a complicated intracellular pathway, which leads to cell growth and …