Sertoli cells isolated from the adult mouse and human testis resume proliferation in culture.
After 20 days of culture in Dulbecco modified Eagle medium/Ham F12 (DMEM/F12) medium …

Much of what is known about the molecular regulation and function of adult Sertoli cells has
been inferred from in vitro studies of immature Sertoli cells. However, adult and immature …

Sertoli cells are essential regulators of spermatogenesis, and each Sertoli cell is capable of
supporting a limited number of germ cells to maturity (Orth et al., 1988). Therefore, the …

The pattern of Sertoli cell replication in maturing rat testes was investigated in vivo and in
organ culture, using pulse labeling with 3H-thymidine and radioautography. The labeling …

Conventionally, it was believed that Sertoli cells (SC) stopped proliferating at puberty and
became terminally differentiated quiescent cells. However, recent studies have challenged …

It is widely held that the somatic cell population that is responsible for sperm development
and output (Sertoli cells) is terminally differentiated and unmodifiable in adults. It is …

New data have challenged the convention that the adult Sertoli cell population is fixed and
unmodifiable. The Sertoli cell has two distinct functions: 1) formation of the seminiferous …

Disorders of testicular function may have their origins in fetal or early life as a result of
abnormal development or proliferation of Sertoli cells. Failure of Sertoli cells to mature, with …

We have developed a rapid and convenient method of Sertoli cell preparation for studying
the growth kinetics of these cells in in vitro culture. Datura Stramonium agglutinin (DSA) …

This study uses a high purity cell culture system to extend previous observations of factors
controlling the end of the Sertoli cell proliferative phase. Thyroid hormone, retinoic acid, and …