Cisplatin (CDDP) is a widely used chemotherapeutic agent for various solid tumors, but its
severe side effects, particularly nephrotoxicity, limit its clinical application. Isoorientin (Iso) is …

Oxidative stress and inflammation are considered to be the main pathogenesis of cisplatin
nephrotoxicity. Astilbin, a flavonoid with anti-oxidation and anti-inflammation function, has …

Cisplatin is an effective antineoplastic agent widely used in the treatment of solid tumors,
however, it induces nephrotoxicity. Cisplatin-induced nephrotoxicity is associated with …

Isoliquiritigenin (IsoLQ) is a flavonoid with antioxidant properties and inducer of
endoplasmic reticulum (ER) stress. In vitro and in vivo studies show that ER stress-mediated …

Acute kidney injury (AKI) is a serious complication in critically ill patients. Accumulating
evidences indicated that macrophages play an important pro-inflammatory role in AKI and …

Cisplatin, or DDP, is a highly successful and well-known chemotherapy drug used to treat
cancer. Acquired resistance to chemotherapy is a major clinical concern, yet the …

The use of cisplatin, a chemotherapy drug, is often limited due to its renal side effects such
as acute kidney injury (AKI). However, there are no validated medications to prevent or treat …

Acute kidney injury (AKI) induced by cisplatin (CP), a first-line anticancer drug for
chemotherapy, is common. To date, there is an urgent need to find effective treatments to …

Although cisplatin is a common drug in the treatment of malignant tumors, its clinical
application is limited due to various side effects, especially acute kidney injury (AKI). Till …

Cisplatin (CDDP) is a widely used drug for cancer treatment that exhibits major side effects
in normal tissues, such as nephrotoxicity in kidneys. The Nrf2 signaling pathway, a regulator …