Introduction: Increased systemic inflammation plays a significant role in the development of
adult cardiometabolic diseases such as insulin resistance, dyslipidemia, atherosclerosis …

The complement system has been implicated in obesity, fatty liver, diabetes and
cardiovascular disease (CVD). Complement factors are produced in adipose tissue and …

C3 is the central component of the complement system and activation of C3 via any of the
three major activation pathways—the classical, the lectin and the alternative pathways …

As the common factor linking adipose tissue to the metabolic context of obesity, insulin
resistance and atherosclerosis are associated with a low-grade chronic inflammatory status …

Abundant reports have shown that there is a strong relationship between C3 and C3a-
desArg levels, adipose tissue, and risk factors for cardiovascular disease, metabolic …

BACKGROUND: Complement C3 is an emerging risk factor for coronary heart disease
(CHD) and is particularly increased in the metabolic syndrome. A direct effect of smoking on …

We studied whether serum complement C3 (C3) is an independent determinant of incident
cardiometabolic risk (coronary heart disease [CHD], metabolic syndrome [MetS], and type 2 …

Background: An intricate network of reciprocal interactions between adipose tissue and
immune system have been largely demonstrated, leading to the well-accepted concept of …

Background Complement factor C3 and C4 have been associated with atherosclerosis and
cardiovascular risk factors. This study explored whether plasma levels of C3 and C4 are risk …

Background In several reports, C3 and C4 have been linked to diabetes and cardiovascular
disease (CVD). Here, we investigate this link and the degree of C3 activation in elderly …