Advanced age causes skeletal muscle to undergo deleterious changes including muscle
atrophy, fast-to-slow muscle fiber transition, and an increase in collagenous material that …

Muscle and bone are anatomically and functionally closely connected. The traditional
concept that skeletal muscles serve to load bone and transform skeletal segments into a …

Aging is associated with a progressive loss of bone-muscle mass and strength. When the
decline in mass and strength reaches critical thresholds associated with adverse health …

The purposes of this study were to determine the effects of ovarian hormone removal on
force-generating capacities and contractile proteins in soleus and extensor digitorum longus …

Key points• The ageing‐related impairment of muscle function and consequent falls and fall‐
related injuries have severe negative effects on morbidity and mortality in old age, with …

Much has been written about the effects of aging on reproductive function, especially female
fertility. Much less is known about how aging may affect the contractility of the smooth …

All previous aging research on the contractility of rodent skeletal muscle has been
conducted on male rodents. Because males and females age differently, we undertook this …

To determine the role of estrogen in skeletal muscle growth, we investigated estrogen
receptor-mediated effects on proliferation in skeletal myoblasts. In L6, C2C12 and Sol8 …

Decreased estrogen production is associated with changes in the skeletal, cardiovascular
and muscular systems. At the level of skeletal muscles, it has been shown that a reduction in …

Investigations using animal models show that estrogen is related to enzyme release,
specifically creatine kinase, from exercised skeletal muscle. In humans, women have lower …