OBJECTIVE: Glutamatergic neurotransmission is important for memory and cognition and is
severely affected in Alzheimer's disease. d-Cycloserine exhibits partial agonist activity at the …

d-cycloserine is a partial agonist on the glycine site of the N-methyl-d-aspartate glutamate
receptor. This double-blind crossover study of 15 mg d-cycloserine in Alzheimer's disease …

Degeneration of cortical glutamatergic projections may contribute to the cognitive decline in
Alzheimer disease (AD). To evaluate whether 1glutamate system stimulation might confer …

We tested the ability of d-cycloserine, a partial glycine agonist acting at the N-methyl-D-
aspartate (NMDA) receptor complex, to improve implicit memory in Alzheimer patients in a …

This multicenter study evaluated the efficacy and safety of cycloserine and measured its
effects on explicit and implicit memory tests in patients with Alzheimer's disease (AD). Four …

Background In a preliminary dose-finding study, D-cycloserine, a partial agonist at the
glycine modulatory site of the glutamatergicN-methyl-D-aspartate (NMDA) receptor …

Background Evidence supports a role for NMDA receptors in learning and memory. These
can be modulated by the antibiotic D‐cycloserine in such a way that the effect of the …

It is shown that D-cycloserine has cognition-enhancing properties in quinolinic acid
hippocampal-lesioned rats. Lesioned rats had a severe impairment of working memory in an …

D-Cycloserine is a partial agonist at the strychnine-insensitive neuronal glycine receptor and
positively modulates the N-methyl-D-aspartate (NMDA) excitatory amino acid receptor …

D-Cycloserine can enhance activation of the NMDA receptor complex and could enhance
the induction of long-term potentiation (LTP). In animals and humans, D-cycloserine can …