Until 2010, colorectal serrated lesions were generally considered as harmless lesions and
reported as hyperplastic polyps (HPs) by pathologists and gastroenterologists. However …

Serrated adenocarcinoma is a recently described subset of colorectal cancer (CRC), which
account for about 10% of all CRCs and follows an alternative pathway in which serrated …

Identification of the serrated neoplasia pathway has improved our understanding of the
pathogenesis of colorectal cancer (CRC). Insights include an increased recognition of the …

In addition to the adenoma to carcinoma sequence, colorectal carcinogenesis can occur via
the serrated pathway. Studies have focused on clarification of categories and molecular …

Serrated polyps have long been thought to lack malignant potential in the human
colorectum. However, identification of the serrated pathway to colorectal cancer based on …

In the past two decades, besides conventional adenoma pathway, a subset of colonic
lesions, including hyperplastic polyps, sessile serrated adenoma/polyps, and traditional …

Background Colorectal sessile serrated adenoma/polyps (SSA/Ps) are considered early
precursor lesions in the serrated neoplasia pathway. Recent studies have shown …

Hyperplastic or serrated polyps were once believed to have little to no clinical significance. A
subset of these polyps are now considered to be precursors to colorectal cancers (CRC) in …

It is currently known that colorectal cancers (CRC) arise from 3 different pathways: the
adenoma to carcinoma chromosomal instability pathway (50%-70%); the mutator “Lynch …

Approximately 30% of colorectal carcinomas develop via the serrated neoplasia pathway
characterized by widespread DNA methylation and frequent BRAF mutation. Serrated …