Protein–protein interfaces are considered difficult targets for small-molecule protein–protein
interaction modulators (PPIMs). Here, we present for the first time a computational strategy …

The ability to target protein–protein interactions (PPIs) with small molecule inhibitors offers
great promise in expanding the druggable target space and addressing a broad range of …

As an essential part of many biological processes, protein–protein interactions (PPIs) offer
exciting and promising opportunities for drug discovery by extension of the druggable target …

Protein–protein interactions (PPIs) are essential, and modulating their function through PPI-
targeted drugs is an important research field. PPI sites are shallow protein surfaces readily …

Protein-protein interactions (PPIs) are ubiquitous biomolecular processes that are central to
virtually all aspects of cellular function. Identifying small molecules that modulate specific …

A core concept behind modern drug discovery is finding a small molecule that modulates a
function of a target protein. This concept has been successfully applied since the mid-1970s …

Protein–protein interfaces (PPIs) are an important class of drug targets. We report on the first
large-scale validation study on docking into PPIs. DrugScore-adapted AutoDock3 and Glide …

Protein-protein interactions (PPIs) have a pivotal role in many biological processes
suggesting that targeting macromolecular complexes will open new avenues for the design …

In the context of protein–protein interactions, the term “hot spot” refers to a residue or cluster
of residues that makes a major contribution to the binding free energy, as determined by …

Protein–protein interactions are implicated in the pathogenesis of many diseases and are
therefore attractive but challenging targets for drug design. One of the challenges in …