To study the cell signaling events leading to 17β-estradiol (E2)-induced acute
cardioprotection, we subjected isolated rat hearts to three 5-min cycles of 10 μM E2 before …

Estrogen has been reported to prevent development of cardiac hypertrophy in female rodent
models and in humans. However, the mechanisms of sex steroid action are incompletely …

Cardiovascular diseases are the major cause of morbidity and mortality in the developed
world, and are increasing in significance in the developing world. Elucidation of the …

The increase in cardiovascular disease and metabolic syndrome incidence following the
onset of menopause has highlighted the role of estrogen as a cardiometabolic protective …

p38 mitogen-activated protein kinase (MAPK) activates a number of heat shock proteins
(HSPs), including HSP27 and αB-crystallin, in response to stress. Activation of HSP27 or αB …

A number of epidemiological and animal studies have suggested a cardioprotective role for
estrogen. This review will focus on the cardioprotective role of estrogen in ischemia …

Background Estrogen has been shown to mediate protection in female hearts against
ischemia-reperfusion (IR) stress. Composed by a Kir6. 2 pore and an SUR2 regulatory …

Cardiac myocytes contain functional estrogen receptors, however, the effect of estrogen on
growth-related signaling pathways such as mitogen-activated protein kinases (MAPK) in the …

Aim: Observational and clinical studies suggest different responses upon sex hormone
replacement therapy in ischaemic heart disease. Few studies, however, have examined the …

Objective Age is a leading risk factor for the development of ischaemic heart disease and
failure. However, the efficacy of cardioprotective strategies designed to rescue the aged …