We examined pressure overload left ventricular (LV) hypertrophy (H) induced by aortic
banding in transgenic mice with cardiac-specific expression of a dominant negative (DN) …

Objective: To investigate the effects of estrogen on left ventricle (LV) mass and collagen
deposition, and on the expression of receptors for estrogen (ERα, ERβ) and Ang II (AT2R …

We investigated the effects of estrogen on global myocardial ischemia-reperfusion injury in
rats that were ovariectomized (Ovx), sham-operated, or ovariectomized and then given 17β …

Estrogen deprivation aggravates cardiac injury after myocardial ischemia and reperfusion
(I/R) injury. Although either estrogen or the dipeptidyl peptidase-4 (DPP-4) inhibitor …

Estrogen is a potent steroid with pleiotropic effects, which have yet to be fully elucidated.
Estrogen has both nuclear and non-nuclear effects. The rapid response to estrogen, which …

Objective The aim of this study was to evaluate the effects of aging on metabolic,
cardiovascular, autonomic, inflammatory, and oxidative stress parameters after ovarian …

The incidence of cardiac hypertrophy, an established risk factor for heart failure, is generally
lower in women compared with men, but this advantage is lost after menopause. Although it …

Objective: Cardiac overexpression of β2-adrenergic receptors (β2ARs) in male mice (MTG4)
results in increased contractility and increased ischemic injury. Considering recent clinical …

Aim Cardiovascular disease (CVD) risk is lower in pre‐menopausal females vs age matched
males. After menopause risk equals or exceeds that of males. CVD protection of pre …

There is a sharp rise in cardiovascular disease (CVD) risk and progression with the onset of
menopause. The 4-vinylcyclohexene diepoxide (VCD) model of menopause recapitulates …