The adenosine A2A receptor is a G-protein-coupled receptor (GPCR) that has been
extensively studied during the past few decades because it offers numerous possibilities for …

Adenosine signalling has long been a target for drug development, with adenosine itself or
its derivatives being used clinically since the 1940s. In addition, methylxanthines such as …

Medicinal chemical approaches have been applied to all four of the adenosine receptor
(AR) subtypes (A1, A2A, A2B, and A3) to create selective agonists and antagonists for each …

Adenosine receptors (ARs) comprise the P1 class of purinergic receptors and belong to the
largest family of integral membrane proteins in the human genome, the G protein-coupled …

Adenosine receptors (ARs) are a four-member subfamily of G protein-coupled receptors and
are major targets of caffeine and theophylline. There are four subtypes of ARs, designated …

Adenosine is involved in a range of physiological and pathological effects through
membrane-bound receptors linked to G proteins. There are four subtypes of adenosine …

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Background: Adenosine is an endogenous purine nucleoside, which mediates a variety of
important biological processes and diseases, such as vasodilation, inflammation, cancer …

The purine nucleoside adenosine is consensually identified as a major local regulator of
tissue function especially when energy supply fails to meet cellular energy demand. Due to …

Adenosine's diverse physiological functions are mediated by four subtypes of receptors (A1,
A2A, A2B and A3). The A1 adenosine receptor pharmacology and therapeutic application of …