Synthesis of a dual functional anti-MDR tumor agent PH II-7 with elucidations of anti-tumor effects and mechanisms
Y Su, X Cheng, Y Tan, Y Hu, Y Zhou, J Liu, Y Xu… - PLoS …, 2012 - journals.plos.org
Multidrug resistance mediated by P-glycoprotein in cancer cells has been a major issue that
cripples the efficacy of chemotherapy agents. Aimed for improved efficacy against resistant …
cripples the efficacy of chemotherapy agents. Aimed for improved efficacy against resistant …
A novel compound RY10-4 downregulates P-glycoprotein expression and reverses multidrug-resistant phenotype in human breast cancer MCF-7/ADR cells
P Xue, X Yang, Y Liu, C Xiong, J Ruan - Biomedicine & pharmacotherapy, 2014 - Elsevier
Abstract P-glycoprotein (P-gp), an important efflux transporter, is encoded by the MDR1
class of genes and is a major element of the multidrug resistance (MDR) phenomenon in …
class of genes and is a major element of the multidrug resistance (MDR) phenomenon in …
A novel indirubin derivative PHII-7 potentiates adriamycin cytotoxicity via inhibiting P-glycoprotein expression in human breast cancer MCF-7/ADR cells
Multidrug resistance (MDR) is a major impediment to the effective chemotherapy of many
human malignancies, and novel MDR reversal agents are desirable for combination therapy …
human malignancies, and novel MDR reversal agents are desirable for combination therapy …
Development of a novel quinoline derivative as a P-glycoprotein inhibitor to reverse multidrug resistance in cancer cells
Multidrug resistance (MDR) is one of conventional cancer chemotherapy's limitations. Our
group previously synthesized a series of quinoline-based compounds in an attempt to …
group previously synthesized a series of quinoline-based compounds in an attempt to …
Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as P-glycoprotein-mediated multidrug resistance inhibitors
Y Gao, W Shi, J Cui, C Liu, X Bi, Z Li, W Huang… - Bioorganic & Medicinal …, 2018 - Elsevier
Multidrug resistance (MDR) is one of the main obstacles of clinical chemotherapy. A great
deal of research shows that the occurrence of drug resistance in various malignant tumors is …
deal of research shows that the occurrence of drug resistance in various malignant tumors is …
Discovery of new tricyclic spiroindole derivatives as potent P-glycoprotein inhibitors for reversing multidrug resistance enabled by a synthetic methodology-based …
T Yu, R Zeng, Y Guan, B Pan, HW Li, J Gu… - RSC Medicinal …, 2024 - pubs.rsc.org
The discovery of novel and highly effective P-gp inhibitors is considered to be an effective
strategy for overcoming tumor drug resistance. In this paper, a phenotypic screening via a …
strategy for overcoming tumor drug resistance. In this paper, a phenotypic screening via a …
Designed P-glycoprotein inhibitors with triazol-tetrahydroisoquinoline-core increase doxorubicin-induced mortality in multidrug resistant K562/A02 cells
M Kairuki, Q Qiu, M Pan, Q Li, J Zhou, H Ghaleb… - Bioorganic & Medicinal …, 2019 - Elsevier
Multidrug resistance (MDR) refers to the cross-resistance of cancer cells to one drug,
accompanied by other drugs with different mechanisms and structures, which is one of the …
accompanied by other drugs with different mechanisms and structures, which is one of the …
Novel benzo five-membered heterocycle derivatives as P-glycoprotein inhibitors: design, synthesis, molecular docking, and anti-multidrug resistance activity
Z Yang, Y Cai, X Yang, Y Li, Q Wu, Y Yu… - Journal of Medicinal …, 2023 - ACS Publications
A proposed strategy to overcome multidrug resistance (MDR) of anticancer drugs in
chemotherapy is to disable the efflux function of P-glycoprotein (P-gp). In this study, based …
chemotherapy is to disable the efflux function of P-glycoprotein (P-gp). In this study, based …
Overcoming multidrug resistance (MDR) in cancer in vitro and in vivo by a quinoline derivative
Multidrug resistance (MDR) mediated by the over expression of drug efflux protein P-
glycoprotein (P-gp) is one of the major impediments to successful treatment of cancer. P-gp …
glycoprotein (P-gp) is one of the major impediments to successful treatment of cancer. P-gp …
Discovery of (quinazolin-6-yl) benzamide derivatives containing a 6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinoline moiety as potent reversal agents against P …
W Xue, K Liu, T Zhang, G Dong, J Wang, J Wang… - European Journal of …, 2024 - Elsevier
Abstract P-glycoprotein (P-gp) is an important factor leading to multidrug resistance (MDR)
in cancer treatment. The co-administration of anticancer drugs and P-gp inhibitors has been …
in cancer treatment. The co-administration of anticancer drugs and P-gp inhibitors has been …