Obesity and cancer: the role of dysfunctional adipose tissue

RCM Van Kruijsdijk, E Van Der Wall… - … , biomarkers & prevention, 2009 - AACR
Overweight and obesity are health problems of epidemic proportions, increasing the risk not
only of cardiovascular disease and type 2 diabetes mellitus but also of various types of …

Molecular mechanisms of cancer development in obesity

MJ Khandekar, P Cohen, BM Spiegelman - Nature Reviews Cancer, 2011 - nature.com
The increasing incidence of obesity and its co-morbid conditions poses a great challenge to
global health. In addition to cardiovascular disease and diabetes, epidemiological data …

Obesity, adipokines and cancer: an update

CH Lee, YC Woo, Y Wang, CY Yeung… - Clinical …, 2015 - Wiley Online Library
Obesity causes dysfunction of adipose tissue, with resultant chronic inflammation and
adverse interplay of various adipokines, sex steroids and endocrine hormones. All these …

Insights into the link between obesity and cancer

SE Ackerman, OA Blackburn, F Marchildon… - Current obesity …, 2017 - Springer
Abstract Purpose of Review Adipocytes have adapted to store energy in the form of lipid and
also secrete circulating factors called adipokines that signal to other tissues to coordinate …

Update on adipose tissue and cancer

KA Brown, PE Scherer - Endocrine reviews, 2023 - academic.oup.com
Adipose tissue is the largest endocrine organ and an accepted contributor to overall energy
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …

Adipose tissue, obesity and adipokines: role in cancer promotion

A Booth, A Magnuson, J Fouts… - … molecular biology and …, 2015 - degruyter.com
Adipose tissue is a complex organ with endocrine, metabolic and immune regulatory roles.
Adipose depots have been characterized to release several adipocytokines that work locally …

[HTML][HTML] Mechanisms linking excess adiposity and carcinogenesis promotion

AI Pérez-Hernández, V Catalán… - Frontiers in …, 2014 - frontiersin.org
Obesity constitutes one of the most important metabolic diseases being associated to insulin
resistance development and increased cardiovascular risk. Association between obesity …

Signals from the adipose microenvironment and the obesity–cancer link—a systematic review

C Himbert, M Delphan, D Scherer, LW Bowers… - Cancer prevention …, 2017 - AACR
Obesity and its associated metabolic dysregulation are established risk factors for many
cancers. However, the biologic mechanisms underlying this relationship remain …

From obesity to cancer: a review on proposed mechanisms

Z Tahergorabi, M Khazaei, M Moodi… - Cell biochemistry and …, 2016 - Wiley Online Library
Nowadays, obesity is considered as a serious and growing global health problem. It is
documented that the overweight and obesity are major risk factors for a series of …

Visceral adiposity, insulin resistance and cancer risk

CL Donohoe, SL Doyle, JV Reynolds - Diabetology & metabolic syndrome, 2011 - Springer
Background There is a well established link between obesity and cancer. Emerging
research is characterising this relationship further and delineating the specific role of excess …