Zinc is an essential nutrient for all organisms because this metal serves as a catalytic or
structural cofactor for many different proteins. Zinc-dependent proteins are found in the …

The importance of zinc in cell physiology is related mainly to its intracellular involvement in
enzyme catalysis, protein structure, protein-protein interactions, and protein-oligonucleotide …

Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …

Zinc is an essential cofactor for the activity and folding of up to ten percent of mammalian
proteins and can modulate the function of many others. Because of the pleiotropic effects of …

Between 5 and 10% of all proteins of a given organism are estimated to require zinc for
function, and hence zinc is essential for almost any given metabolic process. It is therefore of …

In addition to its critical role in normal cell function, growth, and metabolism, zinc is
implicated as a major factor in the development and progression of many pathological …

Structural, catalytic, and regulatory functions of zinc in biology continue to be defined. The
number of genes coding for proteins with zinc-binding domains is conservatively estimated …

Cells maintain zinc concentrations with relatively narrow limits. Nevertheless, physiologically
relevant changes in free Zn (II) pools or changes in Zn bound to specific ligands or within …

Genes that are involved in mammalian zinc transport recently have been cloned. These all
predict proteins with multiple membrane spanning regions, and most have a histidine-rich …

Intracellular homeostasis for zinc is achieved through the coordinate regulation of specific
transporters engaged in zinc influx, efflux, and intracellular compartmentalization. We have …