Organisms orchestrate cellular functions through transcription factor (TF) interactions with
their target genes, although these regulatory relationships are largely unknown in most …

The genomes of bacterial species show enormous plasticity in the function of individual
genes, in genome organization and in regulatory organization. Over millions of years, both …

The influx of high-throughput data and the need for complex models to describe the
interaction of prokaryotic transcription factors (TF) with their target sites pose new challenges …

Evolutionary changes in ancestral regulatory circuits can bring about phenotypic differences
between related organisms. Studies of regulatory circuits in eukaryotes suggest that these …

Understanding the mechanisms that generate variation is a common pursuit unifying the life
sciences. Bacteria represent an especially striking puzzle, because closely related strains …

Related organisms typically respond to a given cue by altering the level or activity of
orthologous transcription factors, which, paradoxically, often regulate expression of distinct …

Recent studies strongly suggest that in bacterial cells the order of genes along the
chromosomal origin-to-terminus axis is determinative for regulation of the growth phase …

Gene expression is regulated by specific transcriptional circuits but also by the global
expression machinery as a function of growth. Simultaneous specific and global regulation …

BACTERIAL REGULATION: GLOBAL REGULATORY NETWORKSl Page 1 Ann. Rev. Genet.
1984. 18:415-41 BACTERIAL REGULATION: GLOBAL REGULATORY NETWORKSl Susan …

Coordinated regulation of gene expression relies on transcription factors (TFs) binding to
specific DNA sites. Our large-scale information–theoretical analysis of> 950 TF-binding …