Forkhead O transcription factors (FOXO) play a pivotal role in the regulation of a myriad of
cellular functions including cell cycle arrest, cell death, and protection from stress stimuli …

Digestive malignancies are the leading cause of mortality among all neoplasms, contributing
to estimated 3 million deaths in 2012 worldwide. The mortality rate hassurpassed lung …

Neoplasms constituted an enormous burden and contributed to an estimated 8.2 million
deaths in 2012 worldwide. FOXO1 (forkhead box O1), a member of the forkhead box (FOX) …

FOXO transcription factors are important regulators of cell fate decisions, capable of
inducing cell death as well as promoting cell survival and resistance to environmental stress …

The PI3K-Akt-FoxO signaling pathway plays a central role in diverse physiological
processes including cellular energy storage, growth, and survival, among others. As an …

Forkhead box O3 (FOXO3a) is a member of a subfamily of forkhead transcription factors
involved in the basic processes within a cell, including proliferation, apoptosis, cell cycle …

Transcription factors are direct effectors of altered signaling pathways in cancer and
frequently determine clinical outcomes in cancer patients. To uncover new transcription …

FOXM1 transcription factor is an oncogene and a master regulator of chemoresistance in
multiple cancers. Pharmacological inhibition of FOXM1 is a promising approach but has …

Forkhead O transcription factors (FOXO) are critical for the regulation of cell cycle arrest, cell
death, and DNA damage repair. Inactivation of FOXO proteins may be associated with …

Abstract Forkhead box O4 (FOXO4) is a member of the FOXO family that regulates a number
of genes involved in metabolism, cell cycle, apoptosis, and cellular homeostasis via …