Simple Summary The spread of breast cancer to distant parts of the body (metastasis) is the
major cause of death in breast cancer patients. Research has shown that apart from the …

Distant metastasis to specific target organs is responsible for over 90% of breast cancer-
related deaths, but the underlying molecular mechanism is unclear. Mounting evidence …

It is now widely accepted that the tumor microenvironment is a pathologically active niche
that shapes tumor nature, evolution and response to treatment. Close interactions between …

Currently, metastasis remains the primary cause of death of patients with breast cancer
despite the important advances in the treatment of this disease. In the complex tumour …

Role of Tumor Microenvironment in Breast Cancer and Targeted Therapies discusses the
current understanding of breast cancer tumor microenvironment components, their role in …

It is now widely accepted that the development and progression of a tumor toward the
malignant phenotype is highly dependent on interactions between tumor cells and the tumor …

Breast cancer evolves thanks to a dense and close interaction with the surrounding tumor
microenvironment (TME). Fibroblasts, leukocytes, blood and lymphatic endothelial cells and …

In recent years, it has been shown that breast cancer consists not only of neoplastic cells,
but also of significant alterations in the surrounding stroma or tumor microenvironment …

Metastasis is the major cause of death for breast cancer patients. Tumors are heterogenous
cellular entities composed of cancer cells and cells of the microenvironment in which they …

Despite diagnostic advances, breast cancer remains the most prevalent cancer among
women in the United States. The armamentarium of treatment options for metastatic disease …