A Novel Tool to Investigate the Early and Late Stages of α-Synuclein Aggregation
The accumulation of an inherently disordered protein α-synuclein (α-syn) aggregates in
brain tissue play a pivotal role in the pathology and etiology of Parkinson's disease …
brain tissue play a pivotal role in the pathology and etiology of Parkinson's disease …
Initial effect of temperature rise on α-synuclein aggregation–entropic forces drive the exposure of protein hydrophobic groups probed by fluorescence spectroscopy
MA Saraiva, MH Florêncio - Journal of Fluorescence, 2023 - Springer
The aberrant formation of α-synuclein (Syn) aggregates, varying in size, structure and
morphology, has been linked to the development of Parkinson's disease. In the early stages …
morphology, has been linked to the development of Parkinson's disease. In the early stages …
O-GlcNAc Modification of α-Synuclein Can Alter Monomer Dynamics to Control Aggregation Kinetics
The intrinsically disordered protein α-Synuclein is identified as a major toxic aggregate in
Parkinson's as well as several other neurodegenerative diseases. Recent work on this …
Parkinson's as well as several other neurodegenerative diseases. Recent work on this …
Early sodium dodecyl sulfate induced collapse of α-synuclein correlates with its amyloid formation
The aggregation of α-synuclein (A-syn) has been implicated strongly in Parkinson's disease
(PD). In vitro studies established A-syn to be a member of the intrinsically disordered protein …
(PD). In vitro studies established A-syn to be a member of the intrinsically disordered protein …
Fast kinetics of environmentally induced α-synuclein aggregation mediated by structural alteration in NAC region and result in structure dependent cytotoxicity
T Srivastava, R Raj, A Dubey, D Kumar… - Scientific Reports, 2020 - nature.com
Aggregation of α-synuclein (α-syn) is associated with the manifestation of various
pathogenic synucleinopathies, including Parkinson's disease attributed to both genetic and …
pathogenic synucleinopathies, including Parkinson's disease attributed to both genetic and …
Unraveling the NaCl concentration effect on the first stages of α-synuclein aggregation
R Ramis, J Ortega-Castro, B Vilanova… - …, 2020 - ACS Publications
Intraneuronal aggregation of the intrinsically disordered protein α-synuclein is at the core of
Parkinson's disease and related neurodegenerative disorders. Several reports show that the …
Parkinson's disease and related neurodegenerative disorders. Several reports show that the …
Site-specific structural dynamics of α-Synuclein revealed by time-resolved fluorescence spectroscopy: a review
S Sahay, G Krishnamoorthy… - Methods and Applications …, 2016 - iopscience.iop.org
Aggregation of α-Synuclein (α-Syn) into amyloid fibrils is known to be associated with the
pathogenesis of Parkinson's disease (PD). Several missense mutations of the α-Syn gene …
pathogenesis of Parkinson's disease (PD). Several missense mutations of the α-Syn gene …
Investigation of intramolecular dynamics and conformations of α-, β-and γ-synuclein
VC Ducas, E Rhoades - PLoS One, 2014 - journals.plos.org
The synucleins are a family of natively unstructured proteins consisting of α-, β-, and γ-
synuclein which are primarily expressed in neurons. They have been linked to a wide variety …
synuclein which are primarily expressed in neurons. They have been linked to a wide variety …
Nanomechanical properties of distinct fibrillar polymorphs of the protein α-synuclein
Abstract Alpha-synuclein (α-Syn) is a small presynaptic protein of 140 amino acids. Its
pathologic intracellular aggregation within the central nervous system yields protein fibrillar …
pathologic intracellular aggregation within the central nervous system yields protein fibrillar …
Early stages for Parkinson's development: α-synuclein misfolding and aggregation
J Yu, YL Lyubchenko - Journal of neuroimmune pharmacology, 2009 - Springer
Misfolding and aggregation of proteins are common threads linking a number of important
human health problems, including various neurodegenerative disorders such as Parkinson's …
human health problems, including various neurodegenerative disorders such as Parkinson's …
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- α synuclein fluorescence spectroscopy
- α synuclein early stages
- α synuclein entropic forces
- α synuclein temperature rise
- α synuclein structural dynamics
- α synuclein nac region
- α synuclein fast kinetics
- α synuclein conformational equilibria
- α synuclein nanomechanical properties
- α synuclein structural alteration