Aim To evaluate the impact of hypoxia and hypoxia mimetic agents (HMA) on the formation
and activity of spheroids by dental pulp cells (DPC). Methodology DPC on agarose‐coated …

Introduction: Postnatal human dental pulp is a potentially promising source of progenitor
cells. Sustaining and amplifying progenitor cell populations would be beneficial for basic …

Tissue engineering strategies based on implanting cellularized biomaterials are promising
therapeutic approaches for the reconstruction of large tissue defects. A major hurdle for the …

Introduction Scaffolds often fail to mimic essential functions of the physiologic extracellular
matrix (ECM) that regulates cell-cell communication in tissue microenvironments. The …

Dental pulp infection and necrosis are widespread diseases. Conventional endodontic
treatments result in a devitalized and weakened tooth. In this work, we synthesized novel …

Creating an optimal microenvironment that mimics the extracellular matrix (ECM) of natural
pulp and securing an adequate blood supply for the survival of cell transplants are major …

INTRODUCTION: Trauma can result in the severing of the dental pulp vessels, leading to
hypoxia and ultimately to pulp necrosis. Improved understanding of mechanisms underlying …

The culture of cells under hypoxia is considered one of the hot topics of tissue engineering,
especially when exploring the proliferation capacity, a critical step for cellular-based …

Stem Cells are characterized by their properties of self renewal and multipotency. These
stem cells are localized inside our body at specialized niches, which are known to have low …

Background/Aim: Spheroid formation is a well-known feature of stem/progenitor cells. Dental
pulp cells (DPCs) cultured in serum-free medium can also form spheroids. However, the …