Purpose The DNA methylation mediated by specific DNA methyltransferases (DNMTs),
results in the epigenetic silencing of multiple genes which are implicated in human breast …

Purpose: Three genes, namely DNA methyltransferase (DNMT) 1, DNMT3A, and DNMT3B,
coding for DNMTs that affect promoter methylation status are thought to play an important …

DNA methyltransferases (DNMTs), including DNMT1, 3a, and 3b, play an important role in
the progression of many malignant tumors. However, it remains unclear whether expression …

Breast cancer arises through the accumulation of multiple genetic alterations and epigenetic
changes such as methylation, which silences gene expression in a variety of cancers. In the …

Background DNA hypermethylation events and other epimutations occur in many
neoplasms, producing gene expression changes that contribute to neoplastic …

Significant reprogramming of epigenome is widely described during pathogenesis of breast
cancer. Transformation of normal cell to hyperplastic cell and to neoplastic phenotype is …

Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …

Breast cancer has become a leading cause of cancer-related deaths in women worldwide.
DNA methylation has been revealed to play an enormously important role in the …

Abstract Knowledge about breast carcinogenesis has accumulated during the last decades
but has barely been translated into strategies for early detection or prevention of this …

A hallmark of cancer is aberrant DNA methylation, consisting of global hypomethylation and
regional hypermethylation of tumor suppressor genes. DNA methyltransferase inhibitors …