Framingham Heart Study genome-wide association: results for pulmonary function measures
Background Pulmonary function measures obtained by spirometry are used to diagnose
chronic obstructive pulmonary disease (COPD) and are highly heritable. We conducted …
chronic obstructive pulmonary disease (COPD) and are highly heritable. We conducted …
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry
Background Pulmonary function decline is a major contributor to morbidity and mortality
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
Spirometric measures of lung function are heritable traits that reflect respiratory health and
predict morbidity and mortality. We meta-analyzed genome-wide association studies for two …
predict morbidity and mortality. We meta-analyzed genome-wide association studies for two …
A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample
Rationale Lung function measures are heritable traits that predict population morbidity and
mortality and are essential for the diagnosis of chronic obstructive pulmonary disease …
mortality and are essential for the diagnosis of chronic obstructive pulmonary disease …
Genome-wide association study identifies five loci associated with lung function
Pulmonary function measures are heritable traits that predict morbidity and mortality and
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …
Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a common, complex disease associated
with substantial morbidity and mortality. COPD is defined by irreversible airflow obstruction; …
with substantial morbidity and mortality. COPD is defined by irreversible airflow obstruction; …
A genome-wide association study of pulmonary function measures in the Framingham Heart Study
The ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) is a
measure used to diagnose airflow obstruction and is highly heritable. We performed a …
measure used to diagnose airflow obstruction and is highly heritable. We performed a …
Interaction of cigarette smoking and polygenic risk score on reduced lung function
Importance The risk of airflow limitation and chronic obstructive pulmonary disease (COPD)
is influenced by combinations of cigarette smoking and genetic susceptibility, yet it remains …
is influenced by combinations of cigarette smoking and genetic susceptibility, yet it remains …
Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease
Chronic obstructive pulmonary disease (COPD) independently associates with an increased
risk of coronary artery disease (CAD), but it has not been fully investigated whether this co …
risk of coronary artery disease (CAD), but it has not been fully investigated whether this co …
Association of lung function genes with chronic obstructive pulmonary disease
WJ Kim, MN Lim, Y Hong, EK Silverman, JH Lee… - Lung, 2014 - Springer
Background Spirometric measurements of pulmonary function are important in diagnosing
and determining the severity of chronic obstructive pulmonary disease (COPD). We …
and determining the severity of chronic obstructive pulmonary disease (COPD). We …